876343-26-9

Usage

Molecular Structure

1H-Pyrazole, 3-nitro-1-(2-phenylethyl)consists of a five-membered pyrazole ring with a nitro group at the 3-position and a phenylethyl group at the 1-position.

Functional Groups

The compound contains a nitro group (-NO2) and a phenyl group (-Ph) attached to the pyrazole ring.

Nitro Compound

The presence of the nitro group makes 1H-Pyrazole, 3-nitro-1-(2-phenylethyl)a nitro compound.

Building Block

The compound is used as a building block in organic synthesis and pharmaceutical research for the synthesis of various compounds.

Versatile Intermediate

The nitro group makes 1H-Pyrazole, 3-nitro-1-(2-phenylethyl)a versatile intermediate for the preparation of a variety of functionalized pyrazoles.

Biological Activity

The compound can be used in the synthesis of biologically active molecules due to the presence of the phenylethyl group.

Aromatic Moiety

The phenyl group provides an aromatic moiety that can potentially contribute to the pharmacological properties of the resulting compounds.

Potential Utility

1H-Pyrazole, 3-nitro-1-(2-phenylethyl)has potential utility in the development of new pharmaceuticals and biologically active compounds.

Upstream product

• 103-63-9 1-phenyl-2-bromoethane 
• 26621-44-3 3-nitro-1H-pyrazole 

Downstream Products

• 876343-25-8 1-phenethyl-1H-pyrazol-3-amine 

Relevant academic research and scientific papers

HETEROARYL COMPOUNDS COMPRISING NITROGEN AND USE THEREOF

The present invention relates to heteroaryl compounds comprising nitrogen and use thereof, and more specifically to compounds which exhibit a remarkable effect on inhibiting proliferation of cancer cells and metastasis and recurrence of cancer, a preparat

Regioselective Synthesis, NMR, and Crystallographic Analysis of N1-Substituted Pyrazoles

A systematic study of the N-substitution reactions of 3-substituted pyrazoles under basic conditions has been undertaken. Regioselective N1-alkylation, -arylation, and -heteroarylation of 3-substituted pyrazoles have been achieved using K2CO3-DMSO. The regioselectivity is justified by the DFT calculations at the B3LYP/6-31G??(d) level. A consistent steric effect on chemical shift has been observed for N-alkyl pyrazole analogues. Twenty-five X-ray crystallographic structures have been obtained to confirm the regiochemistry of the major products.

ARYL-AMINO SUBSTITUTED PYRROLOPYRIMIDINE MULTI-KINASE INHIBITING COMPOUNDS

Compounds represented by Formula (I): or stereoisomers or pharmaceutically acceptable salts thereof, are inhibitors of least two of the Abl, Aurora-A, Blk, c-Raf, cSRC, Src, PRK2, FGFR3, Flt3, Lck, Mekl, PDK-1, GSK3?, EGFR, p70S6K, BMX, SGK, CaMKII, Tie-2