876348-41-3Relevant academic research and scientific papers
Synthesis and pharmacological evaluation of second-generation phosphatidic acid derivatives as lysophosphatidic acid receptor ligands
Durgam, Gangadhar G.,Tsukahara, Ryoko,Makarova, Natalia,Walker, Michelle D.,Fujiwara, Yuko,Pigg, Kathryn R.,Baker, Daniel L.,Sardar, Vineet M.,Parrill, Abby L.,Tigyi, Gabor,Miller, Duane D.
, p. 633 - 640 (2007/10/03)
Short-chain phosphatidic acid derivatives, dioctanoyl glycerol pyrophosphate (DGPP 8:0, 1) and phosphatidic acid 8:0 (PA 8:0, 2), were previously identified as subtype-selective LPA1 and LPA3 receptor antagonists. Recently, we report
Acetal phosphate-derived LPA mimics, PPARgamma activators, and autotaxin inhibitors
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Page/Page column 7; sheet 7, (2010/11/24)
Disclosed are compositions that modulate the effects of extracellular LPA receptors, the intracellular PPARγ receptor, and autotaxin, and methods for their use.
Synthesis and biological evaluation of novel cytotoxic phospholipids for prostate cancer
Gududuru, Veeresa,Hurh, Eunju,Durgam, Gangadhar G.,Hong, Seoung Soo,Sardar, Vineet M.,Xu, Huiping,Dalton, James T.,Miller, Duane D.
, p. 4919 - 4923 (2007/10/03)
A series of serine amide phosphates (SAPs) and serine amide alcohols (SAAs) were prepared and evaluated for their in vitro cytotoxicity against five human prostate cancer cell lines. The SAR and biological activity of the synthesized compounds is reported
