876370-49-9Relevant academic research and scientific papers
Synthesis of alkoxyphthalimide derivatives of p-bis-(2-hydroxy-4-aryl-6- iminothiazolidino[4,5-b]pyrimidin-N6-yl)biphenyls
Singh, Bhawani,Baregama, Lalit Kumar,Sharma, Ranjana,Ahmed, Maqbool,Talesara
, p. 337 - 341 (2007/10/03)
Biphenyl-yl-4,4′-bisthiourea 1 reacts with monochloroacetic acid in presence of anhydrous sodium acetate to furnish p-bis-(2-iminothiazolidin-4-one- N2-yl)biphenyl 2. Condensation of ω-bromoalkoxyphthalimides 3a-c with 2 gave corresponding alkoxyphthalimide derivatives 4a-c. In the compounds 4a-c. reactive methylene group of thiazolidinone ring at position-5 was condensed with araldehydes 5a-c to give p-bis-(3-n-alkoxyphthalimido-5- arylidene-2-iminothiazolidin-4-one-N2-yl)biphenvls 6a-i. The titled compounds 7a-i were synthesized by cyclisation reaction of the compounds 6a-i with urea in the presence of anhydrous sodium acetate in acetic acid medium. In another reaction route, substituted benzaldehydes 5a-c were reacted first with 2 to give p-bis-(5-arylidene-2-iminothiazolidin-4-one-N2-yl)biphenyls 8a-c which could be cyclised with urea to furnish p-bis-(2-hydroxy-4-aryl-6- iminothiazolidino[4,5-b]pyrimidin-N6-yl)biphenyls 9a-c. The compounds 6a-i and 7a-i were also synthesized by condensation reactions of 8a-c and 9a-c with 3a-c respectively.
