876372-94-0

Upstream product

• 348-57-2 2,4-difluorobromobenzene 
• 1996-44-7 2,4-difluorothiophenol 

Downstream Products

• 876372-50-8 6-[(2,4-difluorophenyl)thio]-3-isopropyl-5-methyl[1,2,4]triazolo[4,3-a]pyridine 
• 876372-60-0 3-tert-butyl-6-[(2,4-difluorophenyl)thio][1,2,4]triazolo[4,3-a]pyridine 
• 876461-39-1 C₁₆H₁₃F₂N₃S 
• 876372-77-9 methyl 3-{6-[(2,4-difIuorophenyl)thio][1,2,4]triazolo[4,3-a]pyridin-3-yl}benzoate 
• 1522408-87-2 2,4-difluorophenylsulfur chlorotetrafluoride 
• 1522408-96-3 (2,4-difluorophenyl)pentafluoro-λ⁶-sulfane 

Relevant academic research and scientific papers

Metal Organic Framework 199- Catalyzed Domino Sulfur-Coupling and Transfer Reactions: The Direct Synthesis of Symmetric Diaryl Disulfides from Aryl Halides

Abstract: A highly porous metal–organic framework Cu3 BTC2 (copper(II)-benzene-1,3,5-tricarboxylate) that known as MOF-199 was synthesized, and characterized by common methods including, FT-IR, XRD, EDX, SEM and then used as an efficient and recyclable catalyst for the direct synthesis of symmetric organic disulfides. A variety of symmetric diaryl disulfides with high chemoselectivity can be obtained by domino reaction of aryl halides (and tosylates) and potassium 5-methyl-1,3,4-oxadiazole-2- thiolate, as the base and sulfur-transfer reagent, in the presence of MOF-199. Graphical Abstract: [Figure not available: see fulltext.]

An efficient, one-pot and CuCl-catalyzed route to the synthesis of symmetric organic disulfides via domino reactions of thioacetamide and aryl (alkyl) halides

In this article, a simple, general and novel method for the synthesis of diaryl (dialkyl) disulfides from aryl (alkyl) halides is described. This is a convenient approach that involves the use of commercially available and inexpensive thioacetamide as a sulfur transfer reagent in the domino process for the synthesis of symmetric organic disulfides. Copyright

A novel copper-catalyzed, one-pot synthesis of symmetric organic disulfides from alkyl and aryl halides: Potassium 5-methyl-1,3,4-oxadiazole-2-thiolate as a novel sulfur transfer reagent

A new method is reported for the synthesis of symmetric diaryl and dialkyl disulfides from aryl and alkyl halides in the presence of copper using potassium 5-methyl-1,3,4-oxadiazole-2-thiolate as the base, ligand, and sulfur-transfer reagent.

Continued exploration of the triazolopyridine scaffold as a platform for p38 MAP kinase inhibition

The structure based drug design, synthesis and structure-activity relationship of a series of C6 sulfur linked triazolopyridine based p38 inhibitors are described. The metabolic deficiencies of this series were overcome through changes in the C6 linker fr

Addition of ArSSAr to carbon-carbon multiple bonds using electrochemistry

ArS(ArSSAr)+ (arylbis(arylthio)sulfonium ions), which were generated and accumulated by the electrochemical oxidation of diaryl disulfides (ArSSAr) in CH2Cl2 at -78 °C, reacted with alkenes to give the corresponding diaryl

NOVEL TRIAZOLOPYRIDINE COMPOUNDS

This invention is directed generally to triazolopyridine compounds that generally inhibit p38 kinase, TNF, and/or cyclooxygenase activity. Such triazolopyridine include compounds generally corresponding in structure to the following formula (I): wherein R

NOVEL TRIAZOLOPYRIDINE COMPOUNDS FOR THE TREATMENT OF INFLAMMATION

This invention is directed generally to triazolopyridine compounds that generally inhibit p38 kinase, TNF, and/or cyclooxygenase activity. Such triazolopyridine include compounds generally corresponding in structure to the following formula (I): Wherein R1, R2, R3, R4, and R5are as defined in this specification. This invention also is directed to compositions of such triazolopyridines (particularly pharmaceutical compositions), intermediates for the syntheses of such triazolopyridines, methods for making such triazolopyridines, and methods for treating (including preventing) conditions (typically pathological conditions) associated with p38 kinase activity, TNF activity, and/or cyclooxygenase-2 activity.