876379-79-2

Usage

Uses

Used in Pharmaceutical Industry:
3-bromoH-pyrazolo[1,5-a]pyridine-5-carboxylic acid is used as a reagent in the preparation of pyrazolopyridines, which are a class of compounds with potential therapeutic applications. These pyrazolopyridines have been identified as inhibitors of Cryptosporidium parvum and Cryptosporidium hominis, two protozoan parasites that cause cryptosporidiosis, a diarrheal disease affecting humans and animals.
Used in Antimicrobial Applications:
3-bromoH-pyrazolo[1,5-a]pyridine-5-carboxylic acid is used as an antimicrobial agent for the development of potential drug candidates against cryptosporidiosis. 3-bromoH-pyrazolo[1,5-a]pyridine-5-carboxylic acid's ability to inhibit the growth of Cryptosporidium parvum and Cryptosporidium hominis makes it a promising candidate for the treatment of this disease, which can be particularly severe in immunocompromised individuals.

InChI:InChI=1/C8H5BrN2O2/c9-6-4-10-11-2-1-5(8(12)13)3-7(6)11/h1-4H,(H,12,13)

Upstream product

• 1610611-84-1 methyl 3-bromopyrazolo[1,5-a]pyridine-5-carboxylate 
• 104468-87-3 pyrazolo [1,5-a]pyridine-5-carboxylic acid 
• 1101120-00-6 3-ethyl 5-methyl pyrazolo[1,5-a]pyridine-3,5-dicarboxylate 
• 2459-09-8 4-pyridinecarboxylic acid, methyl ester 

Downstream Products

• 1610611-12-5 N-(4-cyanophenyl)-N-methyl-3-(6-(methylcarbamoyl)pyridin-3-yl)pyrazolo[1,5-a]pyridine-5-carboxamide 
• 1610611-10-3 N-ethyl-N-(5-fluoropyridin-2-yl)-3-(4-(methylcarbamoyl)phenyl)pyrazolo[1,5-a]pyridine-5-carboxamide 
• 1610611-08-9 N-(5-cyanopyridin-2-yl)-N-cyclopropyl-3-(4-(methylcarbamoyl)phenyl)pyrazolo[1,5-a]pyridine-5-carboxamide 
• 1610611-06-7 N-(5-cyanopyridin-2-yl)-N-isopropyl-3-(4-(methylcarbamoyl)phenyl)pyrazolo[1,5-a]pyridine-5-carboxamide 
• 1610611-05-6 N-(5-cyanopyridin-2-yl)-N-ethyl-3-(4-(methylcarbamoyl)phenyl)pyrazolo[1,5-a]pyridine-5-carboxamide 
• 1610610-94-0 3-(6-amino-5-fluoropyridin-3-yl)-N-(4-cyanophenyl)-N-methylpyrazolo[1,5-a]pyridine-5-carboxamide 
• 1610610-93-9 N-(1-(1H-pyrazol-1-yl)propan-2-yl)-3-(4-carbamoylphenyl)-N-(5-cyanopyridin-2-yl)pyrazolo[1,5-a]pyridine-5-carboxamide 
• 1610610-90-6 4-(5-(7-fluoro-3-methyl-3,4-dihydro-2H-benzo[b][1,4]oxazine-4-carbonyl)pyrazolo[1,5-a]pyridin-3-yl)-N-methylbenzamide 
• 1610610-84-8 N-(4-cyanophenyl)-N-methyl-3-(4-(methylcarbamoyl)phenyl)pyrazolo[1,5-a]pyridine-5-carboxamide 
• 1610610-81-5 N-(4-fluorophenyl)-N-methyl-3-(4-(methylcarbamoyl)phenyl)pyrazolo[1,5-a]pyridine-5-carboxamide 
• 1610610-59-7 3-(4-(2-aminoacetamido)phenyl)-N-(4-cyanophenyl)-N-methylpyrazolo[1,5-a]pyridine-5-carboxamide 
• 1610610-58-6 3-(4-aminophenyl)-N-(4-cyanophenyl)-N-methylpyrazolo[1,5-a]pyridine-5-carboxamide 
• 1610610-56-4 N-(4-cyanophenyl)-N-methyl-3-(1H-pyrrolo[2,3-b]pyridin-5-yl)pyrazolo[1,5-a]pyridine-5-carboxamide 
• 1610612-58-2 3-bromo-N-(4-cyanophenyl)-N-cyclopropylpyrazolo[1,5-a]pyridine-5-carboxamide 

Relevant academic research and scientific papers

COMPOUNDS AND COMPOSITIONS FOR THE TREATMENT OF PARASITIC DISEASES

The present invention provides compounds of formula I: [INSERT FORMULA HERE] or a pharmaceutically acceptable salt, tautomer, or stereoisomer, thereof, wherein the variables are as defined herein. The present invention further provides pharmaceutical compositions comprising such compounds and methods of using such compounds for treating, preventing, inhibiting, ameliorating, or eradicating the pathology and/or symptomology of a disease caused by a Plasmodium parasite, such as malaria.

INDOLIZINE CARBOXAMIDES AND THE AZA AND DIAZA DERIVATIVES THEREOF

The invention relates to neuroreceptor-active carboxamide-substituted indolizine derivatives of general formula (I) wherein X represents a group of general formula (X1).