87638-04-8 Usage
Description
Canunonam is an injectable antibiotic, the second monobactam ever developed (the first
being Squibb’s aztreonam). It is highly active against Gram negative bacteria, particularly
pseudomom, and is reportedly effective in the treatment of pneumonia, cystitis,
peritonitis and secondary infections.
Definition
ChEBI: An N-sulfonated monobactam antibiotic.
Brand name
Amasulin
Antimicrobial activity
A synthetic monobactam with activity against common
pathogenic organisms similar to that of aztreonam. It is resistant
to hydrolysis by the common plasmid and chromosomal
β-lactamases, but it can be hydrolyzed by ESBLs.
It is administered intravenously, achieving a concentration
of c. 78 mg/L after a 20-min infusion of 1 g. The plasma halflife
is 1.7 h and the plasma protein binding 18–28%.
Carumonam is almost entirely eliminated in the glomerular
filtrate, probenecid having no effect on excretion; 96%
of labeled compound is found in the urine, with 3% in the
feces. Between 68% and 91% of the dose appears in the urine
within 24 h.
Side effects and clinical use are similar to those of
aztreonam.
Check Digit Verification of cas no
The CAS Registry Mumber 87638-04-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,7,6,3 and 8 respectively; the second part has 2 digits, 0 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 87638-04:
(7*8)+(6*7)+(5*6)+(4*3)+(3*8)+(2*0)+(1*4)=168
168 % 10 = 8
So 87638-04-8 is a valid CAS Registry Number.
InChI:InChI=1/C12H14N6O10S2/c13-11-15-4(3-29-11)7(17-28-2-6(19)20)9(21)16-8-5(1-27-12(14)23)18(10(8)22)30(24,25)26/h3,5,8H,1-2H2,(H2,13,15)(H2,14,23)(H,16,21)(H,19,20)(H,24,25,26)/b17-7-/t5?,8-/m0/s1
