876496-18-3Relevant academic research and scientific papers
Stereoselective preparation and reactions of configurationally defined dialkylzinc compounds
Boudier, Andreas,Darcel, Christophe,Flachsmann, Felix,Micouin, Laurent,Oestreich, Martin,Knochel, Paul
, p. 2748 - 2761 (2007/10/03)
The reaction of cyclic and open-chain diastereomerically pure secondary organoboranes with diisopropylzinc allows the preparation of secondary dialkylzinc reagents with good to excellent retention of configuration as shown by deuterolysis and CuI- and Pd0-mediated reactions with electrophiles. The importance of a high boron-zinc exchange rate to obtain high diastereoselectivity has been shown. Improvement of the configurational stability and stereomeric purity of the zinc intermediates has been obtained by using mono-isopinocampheylborane ((-)-IpcBH2) providing optically active dialkylzinc compounds (up to 96% ee) with enhanced diastereoselectivities.
Stereoselective preparation and reactions of configurationally-defined mixed acyclic dialkylzincs
Darcel, Christophe,Flachsmann, Felix,Knochel, Paul
, p. 205 - 206 (2007/10/03)
Mixed acyclic dialkylzincs are stereoselectively prepared from E- and Z-trisubstituted alkenes.
