87655-25-2Relevant academic research and scientific papers
Optical Rotatory Dispersion Studies. 136. Enzymatic Reduction of 2-Methyl-2-(trideuteriomethyl)cyclohexane-1,3-dione. Unusual Conformation of 2,2-Dimethyl-3-hydroxycyclohexanone
Lu, Yucheng,Barth, Guenther,Kieslich, Klaus,Strong, Phyllis D.,Duax, William L.,Djerassi, Carl
, p. 4549 - 4554 (2007/10/02)
The enzymatic reduction of 2-methyl-2-(trideuteriomethyl)cyclohexane-1,3-dione with Kloeckera magna is not stereospecific with respect to the α center.The reaction product, 2-methyl-2-(trideuteriomethyl)-3-hydroxycyclohexanone, was shown to possess the 3S configuration.The circular dichroism and X-ray crystallographic data lead to the unexpected conclusion that the reduction product assumes the conformation with an axially oriented hydroxyl group.
