87657-41-8

Basic information

• Product Name: (3S)-3-Mercapto-(4-nitrophenyl)methylester-1-pyrrolidinecarboxylicacid
• Synonyms: (3S)-3-Mercapto-(4-nitrophenyl)methylester-1-pyrrolidinecarboxylicacid
• CAS NO: 87657-41-8
• Molecular Formula: C₁₂H₁₄N₂O₄S
• Molecular Weight: 282.31600
• Mol File: 87657-41-8.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: (3S)-3-Mercapto-(4-nitrophenyl)methylester-1-pyrrolidinecarboxylicacid(CAS DataBase Reference)
• NIST Chemistry Reference: (3S)-3-Mercapto-(4-nitrophenyl)methylester-1-pyrrolidinecarboxylicacid(87657-41-8)
• EPA Substance Registry System: (3S)-3-Mercapto-(4-nitrophenyl)methylester-1-pyrrolidinecarboxylicacid(87657-41-8)

Safety Data

• Hazardous Substances Data: 87657-41-8(Hazardous Substances Data)

Usage

Uses

(3S)?-3-?Mercapto-1-?pyrrolidinecarboxyli?c Acid (4-?Nitrophenyl)?methyl Ester is an intermediate in synthesizing Panipenem (P180000), a broad spectrum carbapenem antibacterial and antimicrobial agent working against Gram-negative and Gram-positive organisms.

Upstream product

• 181960-38-3 (S)-3-benzoylthio-N-(p-nitrobenzyloxycarbonyl)pyrrolidine 
• 105601-88-5 (3R)-3-hydroxy-1-(4-nitrobenzyloxycarbonyl)-pyrrolidine 
• 91319-84-5 3-(S)-acetylthio-1-p-nitrobenzyloxycarbonylpyrrolidine 
• 4457-32-3 4-nitrobenzyl chloroformate 
• 91319-85-6 3-(R)-methanesulfonyloxy-1-p-nitrobenzyloxycarbonylpyrrolidine 

Downstream Products

• 90652-16-7 (S)-3-(2-{(2R,3S)-3-[(R)-1-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-4-oxo-azetidin-2-yl}-acetylsulfanyl)-pyrrolidine-1-carboxylic acid 4-nitro-benzyl ester 
• 101151-51-3 (4R,5S,6S)-6-(1-Hydroxy-ethyl)-4-methyl-3-[(S)-1-(4-nitro-benzyloxycarbonyl)-pyrrolidin-3-ylsulfanyl]-7-oxo-1-aza-bicyclo[3.2.0]hept-2-ene-2-carboxylic acid 4-nitro-benzyl ester 
• 90629-00-8 (S)-3-(2-Trimethylsilanyl-acetylsulfanyl)-pyrrolidine-1-carboxylic acid 4-nitro-benzyl ester 

Relevant articles and documents

AN IMPROVED PROCESS FOR THE PREPARATION OF CARBAPENEM ANTIBIOTIC

The present invention relates to an improved process for the preparation of the carbapenem antibiotic of formula (I) or its salts, hydrates and esters. The present invention further provides novel crystalline form of compound of general formula (III), wherein R3 is p-nitrobenzyloxy carbonyl.

SYNTHESIS OF OPTICALLY ACTIVE 3-MERCAPTOPYRROLIDINE DERIVATIVES. SYNTHETIC INTERMEDIATES OF CARBAPENEM RS-533 AND ITS ISOMER

The optically active 3-mercaptopyrrolidine derivatives(3a, 3b, 4a and 4b), which are synthetic intermediates of the carbapenem RS-533 (2a) and its isomer (2b), were synthesized by convenient and practical methods.