876589-24-1Relevant academic research and scientific papers
Novel N-substituted benzimidazole CXCR4 antagonists as potential anti-HIV agents
Miller, John F.,Turner, Elizabeth M.,Gudmundsson, Kristjan S.,Jenkinson, Stephen,Spaltenstein, Andrew,Thomson, Michael,Wheelan, Pat
scheme or table, p. 2125 - 2128 (2010/06/13)
The lead optimization of a series of N-substituted benzimidazole CXCR4 antagonists is described. Side chain modifications and stereochemical optimization led to substantial improvements in potency and protein shift to afford compounds with low nanomolar a
CHEMICAL COMPOUNDS
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Page/Page column 72, (2010/10/20)
The present invention provides novel compounds that demonstrate protective effects on target cells from HIV infection in a manner as to bind specifically to the chemokine receptor, and which affect the binding of the natural ligand or chemokine to a receptor such as CXCR4 and/or CCR5 of a target cell.
