876590-09-9Relevant articles and documents
Kilogram-scale synthesis of the CXCR4 antagonist GSK812397
Boggs, Sharon,Elitzin, Vassil I.,Gudmundsson, Kristjan,Martin, Michael T.,Sharp, Matthew J.
, p. 781 - 785 (2009)
An improved, scalable synthesis of the CXCR4 antagonist GSK812397 is described. This new route was recently scaled up in 50 L fixed equipment to afford 1.2 kg of drug substance in five steps with an overall yield of 20% and >99% chemical and enantiomeric
Amine substituted N-(1H-benzimidazol-2ylmethyl)-5,6,7,8-tetrahydro-8-quinolinamines as CXCR4 antagonists with potent activity against HIV-1
Gudmundsson, Kristjan S.,Sebahar, Paul R.,Richardson, Leah D'Aurora,Miller, John F.,Turner, Elizabeth M.,Catalano, John G.,Spaltenstein, Andrew,Lawrence, Wendell,Thomson, Michael,Jenkinson, Stephen
scheme or table, p. 5048 - 5052 (2010/03/24)
Several novel amine substituted N-(1H-benzimidazol-2ylmethyl)-5,6,7,8-tetrahydro-8-quinolinamines were synthesized which had potent activity against HIV-1. The synthetic approaches adopted allowed for variation of the substitution pattern and resulting ch
CHEMICAL COMPOUNDS
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Page/Page column 34, (2010/11/28)
The present invention provides compounds of formula (I) including salts, solvates, and pharmaceutically acceptable derivatives thereof, pharmaceutical formulations containing them, processes for their preparation, and methods of treatment using them.
CHEMICAL COMPOUNDS
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Page/Page column 117, (2010/10/20)
The present invention provides novel compounds that demonstrate protective effects on target cells from HIV infection in a manner as to bind specifically to the chemokine receptor, and which affect the binding of the natural ligand or chemokine to a receptor such as CXCR4 and/or CCR5 of a target cell.
CHEMICAL COMPOUNDS
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Page/Page column 164-165, (2010/10/20)
The present invention provides novel compounds that demonstrate protective effects on target cells from HIV infection in a manner as to bind specifically to the chemokine receptor, and which affect the binding of the natural ligand or chemokine to a receptor such as CXCR4 and/or CCR5 of a target cell.
CHEMICAL COMPOUNDS
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Page/Page column 72, (2010/11/08)
The present invention provides novel compounds that demonstrate protective effects on target cells from HIV infection in a manner as to bind specifically to the chemokine receptor, and which affect the binding of the natural ligand or chemokine to a recep