876603-01-9Relevant articles and documents
Design and synthesis of piperazine acetate podophyllotoxin ester derivatives targeting tubulin depolymerization as new anticancer agents
Sun, Wen-Xue,Ji, Ya-Jing,Wan, Yun,Han, Hong-Wei,Lin, Hong-Yan,Lu, Gui-Hua,Qi, Jin-Liang,Wang, Xiao-Ming,Yang, Yong-Hua
, p. 4066 - 4074 (2017/08/22)
In this paper, a series of podophyllotoxin piperazine acetate ester derivatives were synthesized and investigated due to their antiproliferation activity on different human cancer cell lines. Among the congeners, C5 manifested prominent cytotoxicity towar