876625-74-0

Upstream product

• 690257-83-1 (3S)-1-[(2S,3S)-2-[(tert-butoxycarbonyl)amino]-3-(4-bromophenyl)-1-oxobutanyl]-3-fluoropyrrolidine 
• 163105-89-3 2-methoxy-pyridine-5-boronic acid 
• 1200-07-3 trans-4-bromocinnamic acid 
• 24424-99-5 di-tert-butyl dicarbonate 
• 690257-79-5 (4R)-3-[(3R)-3-(4-bromophenyl)butanoyl]-4-phenyl-1,3-oxazolidin-2-one 
• 690257-81-9 (4R)-3-[(2S,3S)-2-azido-3-(4-bromophenyl)butanoyl]-4-phenyl-1,3-oxazolidin-2-one 
• 690257-80-8 (4R)-3-[(2R,3S)-2-bromo-3-(4-bromophenyl)butanoyl]-4-phenyl-1,3-oxazolidin-2-one 
• 690257-78-4 (R)-3-(3-(4-bromophenyl)acryloyl)-4-phenyloxazolidin-2-one 
• 690257-82-0 (2R,3S)-2-azido-3-(4-bromophenyl)butanoic acid 

Downstream Products

• 690257-88-6 (3S)-1-[(2S,3S)-2-[(tert-butoxycarbonyl)amino]-3-[4-(6-oxo-1,6-dihydroypyridin-3-yl)phenyl]-1-oxobutanyl]-3-fluoropyrrolidine 
• 690256-63-4 (3S)-1-[(2S,3S)-2-amino-3-[4-(5-bromo-6-oxo-1,6-dihydroypyridin-3-yl)phenyl]-1-oxobutanyl]-3-fluoropyrrolidine trifluoroacetic acid salt 
• 690256-57-6 (3S)-1-[(2S,3S)-2-amino-3-[4-(6-oxo-1,6-dihydropyridin-3-yl)phenyl]-1-oxobutanyl]-3-fluoropyrrolidine hydrochloride 

Relevant academic research and scientific papers

Discovery of potent, selective, and orally bioavailable pyridone-based dipeptidyl peptidase-4 inhibitors

anti-Substituted β-methylphenylalanine derived amides have been shown to be potent DPP-IV inhibitors exhibiting excellent selectivity over both DPP8 and DPP9. The optimized compound exhibited good pharmacokinetic profiles in three preclinical species.

PHENYLALANINE DERIVATIVES AS DIPEPTIDYL PEPTIDASE INHIBITORS FOR THE TREATMENT OR PREVENTION OF DIABETES

The present invention is directed to phenylalanine derivatives which are inhibitors of the dipeptidyl peptidase-IV enzyme ("DP-IV inhibitors") and which are useful in the treatment or prevention of diseases in which the dipeptidyl peptidase-IV enzyme is involved, such as diabetes and particularly type 2 diabetes. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which the dipeptidyl peptidase-IV enzyme is involved.