876625-75-1Relevant academic research and scientific papers
Discovery of potent, selective, and orally bioavailable pyridone-based dipeptidyl peptidase-4 inhibitors
Xu, Jinyou,Wei, Lan,Mathvink, Robert,Edmondson, Scott D.,Mastracchio, Anthony,Eiermann, George J.,He, Huaibing,Leone, Joseph F.,Leiting, Barbara,Lyons, Kathryn A.,Marsilio, Frank,Patel, Reshma A.,Petrov, Aleksandr,Wu, Joseph K.,Thornberry, Nancy A.,Weber, Ann E.
, p. 1346 - 1349 (2006)
anti-Substituted β-methylphenylalanine derived amides have been shown to be potent DPP-IV inhibitors exhibiting excellent selectivity over both DPP8 and DPP9. The optimized compound exhibited good pharmacokinetic profiles in three preclinical species.
