876708-03-1

Basic information

• Product Name: RO 9187
• Synonyms: RO 9187;4-Amino-1-(4-C-azido-beta-D-arabinofuranosyl)-2(1H)-pyrimidinone
• CAS NO: 876708-03-1
• Molecular Formula: C9H12N6O5
• Molecular Weight: 284.22878
• Mol File: 876708-03-1.mol
• Article Data: 4

Chemical Properties

• Melting Point: 188.0-189.0℃
• Appearance: /
• CAS DataBase Reference: RO 9187(CAS DataBase Reference)
• NIST Chemistry Reference: RO 9187(876708-03-1)
• EPA Substance Registry System: RO 9187(876708-03-1)

Safety Data

• Hazardous Substances Data: 876708-03-1(Hazardous Substances Data)

Usage

General Description

RO 9187 is a chemical compound, specifically an opioid receptor antagonist. It is primarily used in the development of medications for the treatment of opioid addiction and overdose. RO 9187 works by blocking the effects of opioids on the receptors in the brain, thus reducing their euphoric and respiratory depressant effects. It has shown promise in preclinical studies for its potential to decrease opioid cravings and prevent relapse in individuals with opioid use disorder. Additionally, it has been investigated for its potential to reverse the effects of opioid overdose, making it a potentially life-saving medication in emergency situations. Its chemical structure and properties make it a valuable tool in the ongoing efforts to combat opioid addiction and overdose.

Upstream product

• 876708-01-9 1-(4'-azido-β-D-arabinofuranosyl)uracil 

Relevant articles and documents

Azido nucleosides and nucleotide analogs

Disclosed herein are 4′-azido-substituted nucleosides, nucleotides and analogs thereof, pharmaceutical compositions that include one or more of 4′-azido-substituted nucleosides, nucleotides and analogs thereof, and methods of synthesizing the same. Also disclosed herein are methods of ameliorating and/or treating a disease and/or a condition, including an infection from a paramyxovirus and/or an orthomyxovirus, with a 4′-azido-substituted nucleoside, a nucleotide and/or an analog thereof. Examples of viral infections include a respiratory syncytial viral (RSV) and influenza infection.

The design, synthesis, and antiviral activity of 4′-azidocytidine analogues against hepatitis C virus replication: The discovery of 4′-azidoarabinocytidine

4′-Azidocytidine 3 (R1479) has been previously discovered as a potent and selective inhibitor of HCV replication targeting the RNA-dependent RNA polymerase of hepatitis C virus, NS5B. Here we describe the synthesis and biological evaluation of several der