876709-87-4Relevant academic research and scientific papers
Ultrasound promoted one-pot synthesis of 2-amino-4,8-dihydropyrano[3,2-b] pyran-3-carbonitrile scaffolds in aqueous media: A complementary 'green chemistry' tool to organic synthesis
Banitaba, Sayed Hossein,Safari, Javad,Khalili, Shiva Dehghan
, p. 401 - 407 (2013)
A green and simple approach to assembling of 2-amino-4,8-dihydropyrano[3,2- b]pyran-3-carbonitrile scaffolds via three-component reaction of kojic acid, malononitrile, and aromatic aldehydes in aqueous media under ultrasound irradiation is described. The combinatorial synthesis was achieved for this methodology with applying ultrasound irradiation while making use of water as green solvent. In comparison to conventional methods, experimental simplicity, good functional group tolerance, excellent yields, short routine, and selectivity without the need for a transition metal or base catalyst are prominent features of this green procedure.
SiO2-OSO3H nanoparticles: An efficient, versatile and new reagent for the one-pot synthesis of 2-amino-8-oxo-4,8-dihydropyrano[3,2-b] pyran-3-carbonitrile derivatives in water, a green protocol
Sadeghi, Bahareh,Nezhad, Parinaz Farokhi,Hashemian, Saeedeh
, p. 54 - 57 (2014/02/14)
In a one-pot three-component reaction, an aromatic or aliphatic aldehyde, malononitrile and 5-hydroxy-2-hydroxymethyl-4H-pyran-4-one were condensed for the synthesis of 2-amino-8-oxo-4,8-dihydropyrano[3,2-b]pyran-3-carbonitrile derivatives in the presence of nano-silica sulfuric acid (SiO 2-OSO3H nanoparticles) in improved yields. The catalyst is recoverable by simple filtration and can be used in the subsequent reactions.
