876746-59-7

Basic information

• Product Name: m-PEG3-NHS ester
• Synonyms: m-PEG3-NHS ester;mPEG2-CH2CH2COONHS Ester
• CAS NO: 876746-59-7
• Molecular Formula: C12H19NO7
• Molecular Weight: 289.28176
• Mol File: 876746-59-7.mol
• Article Data: 0

Chemical Properties

• Appearance: /
• Solubility: Soluble in DMSO, DCM, DMF
• CAS DataBase Reference: m-PEG3-NHS ester(CAS DataBase Reference)
• NIST Chemistry Reference: m-PEG3-NHS ester(876746-59-7)
• EPA Substance Registry System: m-PEG3-NHS ester(876746-59-7)

Safety Data

• Hazardous Substances Data: 876746-59-7(Hazardous Substances Data)

Usage

Description

m-PEG3-NHS ester is a PEG (polyethylene glycol) linker that features an NHS (N-hydroxysuccinimide) ester group. This functional group is specifically designed to react with primary amines (-NH2) present in proteins, amine-modified oligonucleotides, and other molecules containing amine groups. The hydrophilic nature of the PEG spacer enhances the solubility of the conjugated molecules in aqueous environments, making m-PEG3-NHS ester a versatile tool in various applications.

Uses

Used in Bioconjugation:
m-PEG3-NHS ester is used as a bioconjugation agent for attaching proteins, peptides, and other amine-containing molecules to a PEG chain. This process is crucial for improving the stability, solubility, and bioavailability of these biomolecules, as well as for controlling their pharmacokinetics and biodistribution.
Used in Drug Delivery Systems:
In the pharmaceutical industry, m-PEG3-NHS ester is used as a component in drug delivery systems. It aids in the development of PEGylated drugs, which can enhance the circulation time, reduce immunogenicity, and improve the therapeutic efficacy of the drug molecules.
Used in Diagnostics and Imaging:
m-PEG3-NHS ester is utilized in the development of diagnostic and imaging agents. By conjugating targeting molecules or imaging agents with PEG, it allows for better distribution and clearance from the body, leading to improved imaging contrast and reduced background noise.
Used in Biosensor Development:
In the field of biosensors, m-PEG3-NHS ester is employed as a key component in the fabrication of sensor surfaces. The PEGylation of sensor surfaces can prevent non-specific binding, enhance the stability of the immobilized biomolecules, and improve the overall performance of the biosensors.
Used in Tissue Engineering and Regenerative Medicine:
m-PEG3-NHS ester is used as a component in the development of hydrogels and scaffolds for tissue engineering and regenerative medicine. The PEGylation of these materials can improve their biocompatibility, promote cell adhesion and growth, and provide a more favorable environment for tissue regeneration.
Used in Cosmetics and Personal Care Products:
In the cosmetics and personal care industry, m-PEG3-NHS ester is used to modify ingredients, such as peptides and proteins, to enhance their stability, solubility, and bioavailability. This modification can lead to improved efficacy and performance of the final products.