87693-72-9Relevant academic research and scientific papers
Syntesis of the new tricyclic system thieno pyridopyrazin-4-one
Frehel, Daniel,Maffrand, Jean-Pierre
, p. 143 - 149 (2007/10/02)
The new tricyclic system thienopyrido(1,2-a)pyrazin-4-one, a thiophenic isostere of the heterocyclic system pyrazino(1,2-a)isoquinolin-4-one is synthesised by cyclization in acidic medium from 4-acyl-6-hydroxy-1-piperazin-
NEW SYNTHESES OF PRAZIQUANTEL : 2-(CYCLOHEXYLCARBONYL)-1,2,3,6,7,11b-HEXAHYDRO-4H-PYRAZINOISOQUINOLIN-4-ONE
Frehel, Daniel,Maffrand, Jean-Pierre
, p. 1731 - 1735 (2007/10/02)
This paper describes two different synthetic pathways for praziquantel, a new broad spectrum schistosomicide and cestocide.Easy to apply on an industrial scale, they involve a selective reduction of 4-acyl-1-phenethylpiperazine-2,6-dione in 4-acyl-6-hydroxy-1-phenethylpiperazin-2-one, the cyclisation of wchich in acetic medium gives tricyclic compounds 2-acyl-1,2,3,6,7,11b-hexahydro-4H-pyrazinisoquinolin-4-one.
