87693-97-8

Upstream product

• 5147-80-8 [Bis(methylthio)methylene]malononitrile 
• 619-56-7 4-chlorobenzamide 
• 104-88-1 4-chlorobenzaldehyde 
• 107427-79-2 (E)-3-amino-2-cyano-3-(methylsulfanyl)acrylamide 
• 79388-68-4 N-(Bis-methylsulfanyl-methylene)-4-chloro-benzamide 
• 107-91-5 cyanoacetic acid amide 

Relevant academic research and scientific papers

A Novel One-Pot Method for the Synthesis of Pyrimidine Derivatives Using Ketene N,S-Acetal with Aryl Aldehydes

(Chemical Equation Presented) A very simple and facile one-pot method for the synthesis of pyrimidine derivatives is presented. In this method, 2-aryl-pyrimidine derivatives were prepared by the reaction of ketene N,S-acetal 1 with commercially available aryl aldehydes by heating under solvent and catalyst-free conditions. The synthesized pyrimidine derivatives showed blue-green fluorescence in solid state.

REACTION OF KETENETHIOACETALS WITH CARBOXAMIDES

Reaction of methyl 2-cyano-3,3-bis(methylthio)-acrylate (1a) with carboxamides in the presence of sodium hydride in a mixture of benzene and N,N-dimethylacetamide gave the corresponding displacement products of methylthio group, methyl 3-(N-alkyl or aryl)carbamoyl-2-cyano-3-(methylthio)-acrylates (3a,b,c,d,e,f,g,h).Refluxing of 3 in methanol gave the corresponding cyclized product, 2-alkyl or 2-aryl-5-methoxycarbonyl-6-methylthio-4(3H)-pyrimidones (4).Compound 3a was allowed to react with amine(morpholine, benzylamine, cyclohexylamine, aniline) to give 4-(substituted amino)-4(3H)-pyrimidone derivatives (6a,b,c,d).