877080-99-4Relevant articles and documents
Asymmetric synthesis of substituted azetidine type α- and β-amino acids
Enders, Dieter,Gries, Joerg
, p. 3508 - 3516 (2005)
A versatile asymmetric synthesis of 3-substituted azetidine-2-carboxylic acids and 2-substituted azetidine-3-carboxylic acids via 1,3-amino alcohols with excellent stereoselectivities (de ≥ 96%, ee ≥ 96%) is reported. The high asymmetric inductions were achieved employing the SAMP/RAMP-hydrazone methodology. A phenyl moiety was used as a synthetic equivalent of the carboxylic acid function. In addition, the amino acids prepared were tested as organocatalysts in an asymmetric aldol reaction. Georg Thieme Verlag Stuttgart.
