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CAS

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877125-98-9

7-AMINOMETHYL-SPIRO[3.5]NONANE, also known as ASPO, is a novel bicyclic amine with a unique spiro[3.5]nonane ring system. It has demonstrated activity as an agonist at the α7 nicotinic acetylcholine receptor and has shown potential as an anti-inflammatory and neuroprotective agent. ASPO's unique structure and promising pharmacological profile make it an interesting compound for further research and possible drug development.

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  • 877125-98-9 Structure

  • Basic information

    1. Product Name: 7-AMINOMETHYL-SPIRO[3.5]NONANE
    2. Synonyms: 7-AMINOMETHYL-SPIRO[3.5]NONANE;Spiro[3.5]nonan-7-ylMethanaMine
    3. CAS NO:877125-98-9
    4. Molecular Formula: C10H19N
    5. Molecular Weight: 153.27
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 877125-98-9.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: 212.9±8.0 °C(Predicted)
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: 0.95±0.1 g/cm3(Predicted)
    6. Refractive Index: N/A
    7. Storage Temp.: 2-8°C(protect from light)
    8. Solubility: N/A
    9. PKA: 10.22±0.29(Predicted)
    10. CAS DataBase Reference: 7-AMINOMETHYL-SPIRO[3.5]NONANE(CAS DataBase Reference)
    11. NIST Chemistry Reference: 7-AMINOMETHYL-SPIRO[3.5]NONANE(877125-98-9)
    12. EPA Substance Registry System: 7-AMINOMETHYL-SPIRO[3.5]NONANE(877125-98-9)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 877125-98-9(Hazardous Substances Data)

877125-98-9 Usage

Uses

Used in Pharmaceutical Industry:
7-AMINOMETHYL-SPIRO[3.5]NONANE is used as a pharmacological agent for its agonistic activity at the α7 nicotinic acetylcholine receptor. This makes it a potential candidate for the development of drugs targeting this receptor subtype, which could be beneficial in treating various neurological and cognitive disorders.
Used in Anti-inflammatory Applications:
7-AMINOMETHYL-SPIRO[3.5]NONANE is used as an anti-inflammatory agent due to its potential to modulate inflammatory processes. This property could be harnessed in the development of treatments for inflammatory diseases and conditions.
Used in Neuroprotective Applications:
7-AMINOMETHYL-SPIRO[3.5]NONANE is used as a neuroprotective agent, offering potential benefits in protecting neurons from damage and degeneration. Its neuroprotective properties could be valuable in the development of therapies for neurodegenerative diseases such as Alzheimer's and Parkinson's.

Check Digit Verification of cas no

The CAS Registry Mumber 877125-98-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,7,7,1,2 and 5 respectively; the second part has 2 digits, 9 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 877125-98:
(8*8)+(7*7)+(6*7)+(5*1)+(4*2)+(3*5)+(2*9)+(1*8)=209
209 % 10 = 9
So 877125-98-9 is a valid CAS Registry Number.

877125-98-9SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 18, 2017

Revision Date: Aug 18, 2017

1.Identification

1.1 GHS Product identifier

Product name Spiro[3.5]nonan-7-ylmethanamine

1.2 Other means of identification

Product number -
Other names spiro[3.5]nonan-7-ylmethanamine

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:877125-98-9 SDS

877125-98-9Upstream product

877125-98-9Downstream Products

877125-98-9Relevant articles and documents

Overcoming hERG issues for brain-penetrating cathepsin S inhibitors: 2-Cyanopyrimidines. Part 2

Irie, Osamu,Kosaka, Takatoshi,Kishida, Masashi,Sakaki, Junichi,Masuya, Keiichi,Konishi, Kazuhide,Yokokawa, Fumiaki,Ehara, Takeru,Iwasaki, Atsuko,Iwaki, Yuki,Hitomi, Yuko,Toyao, Atsushi,Gunji, Hiroki,Teno, Naoki,Iwasaki, Genji,Hirao, Hajime,Kanazawa, Takanori,Tanabe, Keiko,Hiestand, Peter C.,Malcangio, Marzia,Fox, Alyson J.,Bevan, Stuart J.,Yaqoob, Mohammed,Culshaw, Andrew J.,Hart, Terance W.,Hallett, Allan

scheme or table, p. 5280 - 5284 (2009/05/07)

We describe here orally active and brain-penetrant cathepsin S selective inhibitors, which are virtually devoid of hERG K+ channel affinity, yet exhibit nanomolar potency against cathepsin S and over 100-fold selectivity to cathepsin L. The new

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