877129-27-6Relevant academic research and scientific papers
Structure-activity relationships within a series of caspase inhibitors. Part 2: Heterocyclic warheads
Ullman, Brett R.,Aja, Teresa,Chen, Ning,Diaz, Jose-Luis,Gu, Xin,Herrmann, Julia,Kalish, Vincent J.,Karanewsky, Donald S.,Kodandapani, Lalitha,Krebs, Joseph J.,Linton, Steven D.,Meduna, Steven P.,Nalley, Kip,Robinson, Edward D.,Roggo, Silvio P.,Sayers, Robert O.,Schmitz, Albert,Ternansky, Robert J.,Tomaselli, Kevin J.,Wu, Joe C.
, p. 3632 - 3636 (2007/10/03)
Various heterocyclic hetero-methyl ketones of the 1-naphthyloxyacetyl-Val- Asp backbone have been prepared. A study of their structure-activity relationship (SAR) related to caspase-1, -3, -6, and -8 is reported. Their efficacy in a cellular model of cell death is also discussed. Potent broad-spectrum caspase inhibitors have been identified.
