877162-94-2Relevant academic research and scientific papers
Palladium-catalysed cross-coupling as a key step in the synthesis of pyridyl-benzamides, -benzylamines and -sulfonamides
Changunda, Charles R.K.,Basson, Adriaan E.,van Vuuren, Sandy F.,Rousseau, Amanda L.,Bode, Moira L.
, p. 137 - 147 (2017)
Novel N-, O- and S-substituted pyridyl-benzamides, -benzylamines and -sulfonamides were prepared by means of palladium-catalysed cross-coupling reactions. The synthetic approach, using Pd2(dba)3as palladium source and rac-BINAP as supporting ligand, proved to be successful for C[sbnd]N, C[sbnd]O and C[sbnd]S cross-coupling reactions. One of the substrates underwent an unexpected nucleophilic aromatic substitution of fluorine, rather than the expected C[sbnd]N cross-coupling reaction.
