877309-59-6

Usage

Uses

Used in Pharmaceutical Research and Development:
2H-1,2,3-Triazole-4-carboxylic acid, methyl ester (9CI) is utilized as a building block for the synthesis of various biologically active molecules, contributing to the advancement of pharmaceuticals with potential therapeutic applications.
Used in the Production of Triazole Derivatives:
2H-1,2,3-Triazole-4-carboxylic acid, methyl ester (9CI) acts as a key intermediate in the production of triazole derivatives, which are valuable in the fields of medicine, agriculture, and material science due to their diverse properties and potential uses.
Used in Medicine:
2H-1,2,3-Triazole-4-carboxylic acid, methyl ester (9CI) is employed as a starting material for the development of new drugs, particularly those with antimicrobial and antifungal properties, addressing the need for novel treatments in the medical field.
Used in Agriculture:
In the agricultural industry, 2H-1,2,3-Triazole-4-carboxylic acid, methyl ester (9CI) is used as a precursor for the development of agrochemicals, specifically those with antifungal properties, to protect crops from fungal infections and enhance yield.
Used in Material Science:
2H-1,2,3-Triazole-4-carboxylic acid, methyl ester (9CI)'s unique properties also make it suitable for applications in material science, where it can be incorporated into the development of new materials with specific properties, such as antimicrobial coatings or materials with enhanced stability.

Upstream product

• 922-67-8 propynoic acid methyl ester 

Downstream Products

• 62289-79-6 methyl 2-phenyl-2H-1,2,3-triazole-4-carboxylate 

Relevant academic research and scientific papers

Discovery of N-(4-{[5-Fluoro-7-(2-methoxyethoxy)quinazolin-4-yl]amino}phenyl)-2-[4-(propan-2-yl)-1 H-1,2,3-triazol-1-yl]acetamide (AZD3229), a Potent Pan-KIT Mutant Inhibitor for the Treatment of Gastrointestinal Stromal Tumors

While the treatment of gastrointestinal stromal tumors (GISTs) has been revolutionized by the application of targeted tyrosine kinase inhibitors capable of inhibiting KIT-driven proliferation, diverse mutations to this kinase drive resistance to establish

Two-step activity-based protein profiling of diacylglycerol lipase

Diacylglycerol lipases (DAGL) produce the endocannabinoid 2-arachidonoylglycerol, a key modulator of neurotransmitter release. Chemical tools that visualize endogenous DAGL activity are desired. Here, we report the design, synthesis and application of a triazole urea probe for DAGL equipped with a norbornene as a biorthogonal handle. The activity and selectivity of the probe was assessed with activity-based protein profiling. This probe was potent against endogenous DAGLα (IC50 = 5 nM) and it was successfully applied as a two-step activity-based probe for labeling of DAGLα using an inverse electron-demand Diels-Alder ligation in living cells.