877314-88-0Relevant academic research and scientific papers
N-SUBSTITUTED PEPTIDOMIMETIC INHIBITORS OF DIPEPTIDYLPEPTIDASE IV
-
Page/Page column 50-51, (2008/12/04)
One aspect of the present invention relates to inhibitors of post-pro line protease enzymes, such as inhibitors of dipeptidyl peptidase IV (DPIV). Other aspects of the invention relate to pharmaceutical compositions and methods of use thereof. In certain embodiments, a DPIV inhibitor comprises a carboxylic acid-containing side chain moiety at the P1 or P2 position or both. The inhibitors of the invention should possess improved specificity for the targeted protease and low toxicity.
