877317-15-2Relevant academic research and scientific papers
Discovery and SAR of hydantoin TACE inhibitors
Yu, Wensheng,Guo, Zhuyan,Orth, Peter,Madison, Vincent,Chen, Lei,Dai, Chaoyang,Feltz, Robert J.,Girijavallabhan, Vinay M.,Kim, Seong Heon,Kozlowski, Joseph A.,Lavey, Brian J.,Li, Dansu,Lundell, Daniel,Niu, Xiaoda,Piwinski, John J.,Popovici-Muller, Janeta,Rizvi, Razia,Rosner, Kristin E.,Shankar, Bandarpalle B.,Shih, Neng-Yang,Arshad Siddiqui,Sun, Jing,Tong, Ling,Umland, Shelby,Wong, Michael K.C.,Yang, De-yi,Zhou, Guowei
scheme or table, p. 1877 - 1880 (2010/07/04)
We disclose inhibitors of TNF-α converting enzyme (TACE) designed around a hydantoin zinc binding moiety. Crystal structures of inhibitors bound to TACE revealed monodentate coordination of the hydantoin to the zinc. SAR, X-ray, and modeling designs are d
HYDANTOIN DERIVATIVES FOR THE TREATMENT OF INFLAMMATORY DISORDERS
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Page column 83, (2008/06/13)
This invention relates to compounds of Formula (1) or a pharmaceutically acceptable salt, solvate or isomer thereof, which can be useful for the treatment of diseases or conditions mediated by MMPs, ADAMs, TACE, TNF- or combinations thereof.
