877399-34-3

Usage

Uses

Used in Organic Synthesis:
1-Boc-3-(4-Bromo-1H-pyrazol-1-yl)azetidine is used as a building block in organic synthesis for its unique structural properties, enabling the creation of various complex organic molecules.
Used in Pharmaceutical Research:
1-Boc-3-(4-Bromo-1H-pyrazol-1-yl)azetidine is utilized as a key intermediate in pharmaceutical research, where its potential biological activities can be explored for the development of new drugs and therapeutic agents.
Used in Medicinal Chemistry:
In the field of medicinal chemistry, 1-Boc-3-(4-Bromo-1H-pyrazol-1-yl)azetidine is employed as a versatile compound for the design and synthesis of novel bioactive molecules, targeting specific biological pathways and mechanisms.
Used in Chemical Biology:
1-Boc-3-(4-Bromo-1H-pyrazol-1-yl)azetidine serves as a valuable tool in chemical biology, where it can be used to study the interactions between small molecules and biological targets, providing insights into the molecular mechanisms of diseases and potential therapeutic interventions.
Used in Drug Discovery:
1-Boc-3-(4-Bromo-1H-pyrazol-1-yl)azetidine is applied in drug discovery processes, where its unique structural features and potential biological activities can be leveraged to identify and optimize lead compounds for the development of new pharmaceuticals.
Used in Chemical Synthesis Education:
In educational settings, 1-Boc-3-(4-Bromo-1H-pyrazol-1-yl)azetidine can be used as a teaching aid to demonstrate the principles of organic synthesis, protecting group chemistry, and the synthesis of complex organic molecules.

Upstream product

• 2075-45-8 4-bromo-1H-pyrazole 
• 254454-54-1 tert-butyl-3-iodoazetidine-1-carboxylate 
• 141699-58-3 3-methanesulfonyloxy-azetidine-1-carboxylic acid tert-butyl ester 

Downstream Products

• 877399-38-7 5-(1-(azetidin-3-yl)-1H-pyrazol-4-yl)-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)pyridin-2-amine 
• 877399-36-5 tert-butyl 3-(4-(6-amino-5-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)pyridin-3-yl)-1H-pyrazol-1-yl)azetidine-1-carboxylate 
• 877399-35-4 tert-butyl 3-(4-(4,4,5,5,-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl)-azetidine-1-carboxylate 

Relevant academic research and scientific papers

NAPHTHYRIDINES AS INHIBITORS OF HPK1

Naphthyridine compounds and their use as inhibitors of HPK1 are described. The compounds are useful in treating HPK1-dependent disorders and enhancing an immune response. Also described are methods of inhibiting HPK1, methods of treating HPK1-dependent disorders, methods for enhancing an immune response, and methods for preparing the naphthyridine compounds.

Structure based drug design of crizotinib (PF-02341066), a potent and selective dual inhibitor of mesenchymal-epithelial transition factor (c-MET) kinase and anaplastic lymphoma kinase (ALK)

Because of the critical roles of aberrant signaling in cancer, both c-MET and ALK receptor tyrosine kinases are attractive oncology targets for therapeutic intervention. The cocrystal structure of 3 (PHA-665752), bound to c-MET kinase domain, revealed a novel ATP site environment, which served as the target to guide parallel, multiattribute drug design. A novel 2-amino-5-aryl-3-benzyloxypyridine series was created to more effectively make the key interactions achieved with 3. In the novel series, the 2-aminopyridine core allowed a 3-benzyloxy group to reach into the same pocket as the 2,6-dichlorophenyl group of 3 via a more direct vector and thus with a better ligand efficiency (LE). Further optimization of the lead series generated the clinical candidate crizotinib (PF-02341066), which demonstrated potent in vitro and in vivo c-MET kinase and ALK inhibition, effective tumor growth inhibition, and good pharmaceutical properties.

PYRAZOLE-SUBSTITUTED AMINOHETEROARYL COMPOUNDS AS PROTEIN KINASE INHIBITORS

Compounds of formula (1) are provided, as well as methods for their synthesis and use. Preferred compounds are potent inhibitors of the c-Met protein kinase, and are useful in the treatment of abnormal cell growth disorders, such as cancers.