877399-50-3

Basic information

• Product Name: 4-(4-Bromopyrazol-1-yl)piperidine-1-carboxylic acid tert-butyl ester
• Synonyms: 4-(4-Bromo-pyrazol-1-yl)-piperidine-1-carboxylic acid tert-butyl ester;1-(4-BOC-Piperidino)-4-bromopyrazole;(R)-5-broMo-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)pyridin-2-a;1-Boc-4-(4-broMopyrazol-1-yl)piperidine;tert-butyl 4-(4-broMo-1H-pyrazol-1-yl)piperidine-1-carbo×ylate;1-Piperidinecarboxylicacid, 4-(4-broMo-1H-pyrazol-1-yl)-, 1,1-diMethylethyl ester;tert-Butyl 4-(4-bromopyrazol-1-yl)piperidine-1-carboxylate;1-Boc-4-(4-bromo-1H-pyrazol-1-yl)piperidine
• CAS NO: 877399-50-3
• Molecular Formula: C₁₃H₂₀BrN₃O₂
• Molecular Weight: 330.22
• Product Categories: API intermediates;intermediate
• Mol File: 877399-50-3.mol
• Article Data: 17

Chemical Properties

• Melting Point: 77.0 to 81.0 °C
• Boiling Point: 411.482 °C at 760 mmHg
• Flash Point: 202.657 °C
• Appearance: Off-white/Solid
• Density: 1.43
• Refractive Index: 1.594
• Storage Temp.: Room temperature.
• Solubility: soluble in Methanol
• PKA: 0.92±0.19(Predicted)
• CAS DataBase Reference: 4-(4-Bromopyrazol-1-yl)piperidine-1-carboxylic acid tert-butyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(4-Bromopyrazol-1-yl)piperidine-1-carboxylic acid tert-butyl ester(877399-50-3)
• EPA Substance Registry System: 4-(4-Bromopyrazol-1-yl)piperidine-1-carboxylic acid tert-butyl ester(877399-50-3)

Safety Data

• Hazard Codes: Xn
• Statements: 22
• Hazardous Substances Data: 877399-50-3(Hazardous Substances Data)

Usage

General Description

4-(4-Bromopyrazol-1-yl)piperidine-1-carboxylic acid tert-butyl ester is a chemical compound with the molecular formula C15H22BrN3O2. It is a piperidine derivative that contains a bromopyrazole group and a tert-butyl ester functional group. 4-(4-Bromopyrazol-1-yl)piperidine-1-carboxylic acid tert-butyl ester is commonly used in the field of medicinal chemistry for the synthesis of potential pharmaceutical agents and drug candidates. It is also utilized as a building block for the construction of various heterocyclic compounds. The tert-butyl ester moiety provides stability and protection to the carboxylic acid group, allowing for selective modifications and functionalizations. The bromopyrazole group confers unique reactivity and pharmacological properties to the molecule, making it an important scaffold for drug discovery and development.

InChI:InChI=1/C13H20BrN3O2/c1-13(2,3)19-12(18)16-6-4-11(5-7-16)17-9-10(14)8-15-17/h8-9,11H,4-7H2,1-3H3

Upstream product

• 2075-45-8 4-bromo-1H-pyrazole 
• 141699-59-4 1-(tert-butoxycarbonyl)piperidin-4-yl methanesulfonate 
• 118811-07-7 tert-butyl 4-(tosyloxy)piperidin-1-carboxylate 
• 877399-60-5 4-(4-bromo-1H-pyrazol-1-yl)piperidine 
• 24424-99-5 di-tert-butyl dicarbonate 
• 5382-16-1 4-HYDROXYPIPERIDINE 
• 109384-19-2 t-butyl 4-hydroxy piperidine-1-carboxylate 

Downstream Products

• 1076224-00-4 4-(4-formylpyrazol-1-yl)piperidine-1-carboxylic acid tert-butyl ester 
• 1309961-03-2 4-(4-bromo-1H-pyrazol-1-yl)-1-ethylpiperidine 
• 1309960-75-5 N'-{3-[1-(1-ethylpiperidin-4-yl)-1H-pyrazol-4-yl]-5-oxo-5H-benzo[4,5]cyclohepta[1,2-b]pyridin-7-yl}-N,N-dimethylsulfuric diamide 
• 1430727-71-1 tert-butyl 4-(4-(1-(5-acetamido-2',4'-difluorobiphenyl-3-yl)-1H-benzo[d]-imidazol-5-yl)-1H-pyrazol-1-yl)piperidine-1-carboxylate 
• 1430723-67-3 N-(2',4'-difluoro-5-(5-(1-(piperidin-4-yl)-1H-pyrazol-4-yl)-1H-benzo[d]-imidazol-1-yl)biphenyl-3-yl)acetamide 
• 1430728-12-3 tert-butyl 4-(4-(1-(3-acetamido-5-(1H-pyrazol-1-yl)phenyl)-1H-benzo[d]imidazol-5-yl)-1H-pyrazol-1-yl)piperidine-1-carboxylate 
• 1430724-58-5 N-(3-(5-(1-(piperidin-4-yl)-1H-pyrazol-4-yl)-1H-benzo[d]imidazol-1-yl)-5-(1H-pyrazol-1-yl)phenyl)acetamide 
• 1430724-59-6 N-(3-(5-(1-(1-(methylsulfonyl)piperidin-4-yl)-1H-pyrazol-4-yl)-1H-benzo[d]imidazol-1-yl)-5-(1H-pyrazol-1-yl)phenyl)acetamide 
• 1430728-20-3 tert-butyl 4-(4-(3-(5-acetamido-2',4'-difluorobiphenyl-3-yl)-3H-imidazo[4,5-b]pyridin-6-yl)-1H-pyrazol-1-yl)piperidine-1-carboxylate 
• 1430724-66-5 N-(2',4'-difluoro-5-(6-(1-(piperidin-4-yl)-1H-pyrazol-4-yl)-3H-imidazo[4,5-b]pyridin-3-yl)biphenyl-3-yl)acetamide 
• 877399-74-1 tert-butyl 4-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl)piperidine-1-carboxylate 

Relevant articles and documents

SUBSTITUTED PYRAZOLE COMPOUNDS AS TOLL RECEPTOR INHIBITORS

Disclosed are compounds of Formula (I) N-oxides, or salts thereof, wherein G, A, R1, and R5 are defined herein. Also disclosed are methods of using such compounds as inhibitors of signaling through Toll-like receptor 7, or 8, or 9, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating inflammatory and autoimmune diseases.

BIFUNCTIONAL DEGRADERS AND THEIR METHODS OF USE

Described herein are bifunctional degrader compounds, their various targets, their preparation, pharmaceutical compositions comprising them, and their use in the treatment of conditions, diseases, and disorders mediated by various target proteins.

Crizotinib intermediate, preparation method and crizotinib preparation method

The invention relates to a crizotinib intermediate, a preparation method and a crizotinib preparation method, in particular to an intermediate of crizotinib which has the structure of a formula (CZT-5) as shown in the description and the structure of a formula (CZT-9) as shown in the description, a preparation method of the intermediate and a preparation method of a crizotinib with the structure of a formula (CZT-11). The method provided by the invention has the characteristics of short route, high yield, easiness in acquisition of raw materials, high reaction selectivity and the like, chiral resolution is not required in a synthetic process, the utilization rate of the raw materials is increased, the path costs are low, and therefore, the method can meet requirements of large-scale industrial production.