87740-87-2Relevant academic research and scientific papers
Copper-Catalyzed Alkylation of Nitroalkanes with α-Bromonitriles: Synthesis of β-Cyanonitroalkanes
Shimkin, Kirk W.,Gildner, Peter G.,Watson, Donald A.
supporting information, p. 988 - 991 (2016/03/15)
Copper catalysis now enables the efficient C-alkylation of nitroalkanes with α-bromonitriles. Using a simple and inexpensive catalyst, this process provides access to β-cyanonitroalkanes. The method is highly tolerant of various functional groups and substitution patterns. These functionally dense products serve as orthogonally masked 1,3-diamines, which can be revealed selectively for access to differentially substituted diamines. These products can also be exploited for the formation of complex cyanoalkenes and 5-aminoisoxazoles.
A New Reaction of α-Nitro Nitriles: Conversion to β-Nitro Nitriles
Kornblum, Nathan,Singh, Haribansh K.,Boyd, Steven D.
, p. 358 - 362 (2007/10/02)
At room temperature the nitro group of an α-nitro nitrile is readily displaced by nitroparaffin anions with the result that β-nitro nitriles are produced in excellent yields.Evidence is presented for the view that these reactions are electron-transfer cha
