877402-82-9

Usage

Structure

Pyrazine derivative with a trifluoromethyl group attached to the pyrazole ring

Potential applications

Pharmaceutical research and drug development

Use

Building block for the synthesis of novel pharmaceutical compounds with potential therapeutic effects

Advantages

Enhanced biological activity and metabolic stability due to the presence of the trifluoromethyl group

Future possibilities

Discovery of new drugs for various medical conditions through further research and development of 2-(TRIFLUOROMETHYL)PYRAZOLO[1,5-A]PYRAZIN-4-OL and its derivatives.

Upstream product

• 129768-28-1 3-(trifluoromethyl)-1H-pyrazole-5-carboxylic acid 
• 877402-80-7 N-(2,2-dimethoxyethyl)-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide 

Downstream Products

• 877402-79-4 4-chloro-2-(trifluoromethyl)pyrazolo[1,5-a]pyrazine 

Relevant academic research and scientific papers

HETEROCYCLIC COMPOUND AND HARMFUL ARTHROPOD CONTROL COMPOSITION CONTAINING SAME

The present invention provides a compound having an excellent control effect on a harmful arthropod. A compound represented by formula (I) [wherein: Q represents a group represented by Q1 or a group represented by Q2; Z represents an oxygen atom or the like; A2 represents CR4a or the like; A3 represents a nitrogen atom, CR4b, or the like; B1 represents CR1 or the like; B2 represents a nitrogen atom, CR6b, or the like; B3 represents a nitrogen atom, CR6c, or the like; G1 represents a nitrogen atom or CR3a; G2 represents a nitrogen atom or CR3b; G3 represents a nitrogen atom or CR3c; G4 represents a nitrogen atom or CR3d; R1 represents a C1-C6 chain hydrocarbon group substituted with one or more substituent(s) selected from the group consisting of a cyano group and a halogen atom or the like; R2 represents a C1-C6 alkyl group or the like; R3a, R3b, R3c, and R3d are identical to or different from each other, and each represent a C1-C6 chain hydrocarbon group or the like; R4a, R4b, R6b, and R6c are identical to or different from each other, and each represent a hydrogen atom or the like; and n represents 0, 1, or 2] or an N-oxide thereof has an excellent control effect on a harmful arthropod.

Synthesis of 8Н-pyrazolo[5',1':3,4]pyrazino[2,1-b]quinazolin-8-ones

[Figure not available: see fulltext.] 4-Chloropyrazolo[1,5-а]pyrazines reacted with anthranilic acids forming 8Н-pyrazolo[5',1':3,4]pyrazino[2,1-b]quinazolin-8-ones representing a new heterocyclic system.

FUSED TRIAZOLE DERIVATIVES AS DIPEPTIDYL PEPTIDASE-IV INHIBITORS FOR THE TREATMENT OR PREVENTION OF DIABETES

The present invention is directed to novel fused triazole derivatives which are inhibitors of the dipeptidyl peptidase-IV enzyme ("DPP-IV inhibitors") and which are useful in the treatment or prevention of diseases in which the dipeptidyl peptidase-IV enzyme is involved, such as diabetes and particularly type 2 diabetes. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which the dipeptidyl peptidase-IV enzyme is involved.