87745-18-4

Usage

Uses

Used in Clinical Toxicology:
2-(PROPYL-3,3,3-D3)PENTANOIC-5,5,5-D3 ACID is used as an internal standard for the quantitation of valproic acid levels in urine or other matrices, aiding in the assessment of potential drug toxicity and overdose situations.
Used in Forensic Analysis:
In forensic analysis, 2-(PROPYL-3,3,3-D3)PENTANOIC-5,5,5-D3 ACID serves as a certified spiking solution to accurately determine the presence and concentration of valproic acid in biological samples, which can be crucial in legal investigations.
Used in Medication Monitoring:
2-(PROPYL-3,3,3-D3)PENTANOIC-5,5,5-D3 ACID is utilized as a reference compound in medication monitoring, ensuring that patients are receiving the appropriate dosage of valproic acid for effective treatment.
Used in Urine Drug Testing:
As a certified spiking solution, 2-(PROPYL-3,3,3-D3)PENTANOIC-5,5,5-D3 ACID is employed in urine drug testing to verify the presence of valproic acid and monitor compliance with prescribed medication regimens.
Used in Therapeutic Drug Monitoring:
2-(PROPYL-3,3,3-D3)PENTANOIC-5,5,5-D3 ACID is used as an internal standard in therapeutic drug monitoring, helping to maintain optimal valproic acid levels for the treatment of epilepsy, bipolar disorder, migraine headaches, and depression.

InChI:InChI=1/C8H16O2/c1-3-5-7(6-4-2)8(9)10/h7H,3-6H2,1-2H3,(H,9,10)/i1D3,2D3

Upstream product

• 99-66-1 valproic acid 

Relevant academic research and scientific papers

Use of hexadeuterated valproic acid and gas chromatography-mass spectrometry to determine the pharmacokinetics of valproic acid

Di-([13,3,3-2H3]propyl)acetic acid, a hexadeuterated analogue of valproic acid, was synthesized and its pharmacolinetic properties compared with valproic acid. Concentrations of valproic acid and [2H]valproic acid in serum and saliva were determined by GC-MS using selected-ion monitoring. Saliva drug levels were measured with good precision down to 0.1 μg/mL. Kinetic equivalence of valproic acid and [2H]valproic acid was demonstrated in a single-dose study in a human volunteer. An isotope effect was observed for ω-oxidation, but the difference in metabolism was not sufficient to make [2H]valproic acid biologically nonequivalent. The application of [2H]valproic acid to determine the kinetics of valproic acid under steady-state concentrations was evaluated in the same volunteer. The kinetic data obtained with [2H]valproic acid was consistent with previously reported values for valproic acid including kinetic differences observed between single-dose and steady-state experiments. Saliva levels of valproic acid were found to give a good correlation (r = 0.953) with total serum valproic acid under multiple-dose conditions. A concentration dependence was found for the ratio of saliva valproic acid to free valproic acid in serum, low ratios being observed at high serum concentrations of valproic acid.

Mild and Direct Multiple Deuterium-Labeling of Saturated Fatty Acids

We have established a mild and direct platinum on carbon (Pt/C)-catalyzed multi-deuterium labeling of various saturated fatty acids including bioactive compounds with high deuterium efficiencies in a mixed solvent of isopropyl alcohol and deuterium oxide