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α,β-Didehydrovaline, also known as 2,3-dehydrovaline, is a non-proteinogenic amino acid that features a double bond between the α and β carbon atoms of the valine side chain. This structural modification results in a more rigid and planar molecule compared to its parent amino acid, valine. α,β-Didehydrovaline is of interest in the field of medicinal chemistry, as it can be incorporated into peptide and protein structures to modulate their properties, such as stability, bioactivity, and conformation. It has been used in the design of constrained peptides and as a building block in the synthesis of various bioactive compounds. The unique chemical properties of α,β-didehydrovaline make it a valuable tool for exploring the effects of structural constraints on peptide and protein function.

87746-81-4

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87746-81-4 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 87746-81-4 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,7,7,4 and 6 respectively; the second part has 2 digits, 8 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 87746-81:
(7*8)+(6*7)+(5*7)+(4*4)+(3*6)+(2*8)+(1*1)=184
184 % 10 = 4
So 87746-81-4 is a valid CAS Registry Number.

87746-81-4Downstream Products

87746-81-4Relevant academic research and scientific papers

Method for synthesizing fluorenylmethoxycarbonyl-2,3-dehydrovaline

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Paragraph 0009, (2019/08/07)

The invention relates to a method for synthesizing fluorenylmethoxycarbonyl-2,3-dehydrovaline. The method mainly solves the technical problem of lack of effective synthesis methods. The synthesis method includes the following steps: reacting Boc-alpha-phosphonomethylglycine trimethyl ester with acetone in a dichloromethane solution under the catalysis of DBU through an HWE to generate a compound 1; heating and hydrolyzing the compound 1 and sodium hydroxide in a mixed solution of methanol and water to generate a compound 2; removing, by the compound 2, a protecting group in the dichloromethanesolution of trifluoroacetic acid to generate a compound 3; and reacting the compound 3, 9-fluorenylmethyl-N-succinimidyl carbonate with sodium bicarbonate in a mixed solution of tetrahydrofuran and water to generate a target compound 4. The fluorenylmethoxycarbonyl-2,3-dehydrovaline, as an amino acid derivative, is mainly used as a pharmaceutical intermediate and in the synthesis of polypeptidesand the like.

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