877460-04-3Relevant academic research and scientific papers
Parallel synthesis of 5-cyano-6-aryl-2-thiouracil derivatives as inhibitors for hepatitis C viral NS5B RNA-dependent RNA polymerase
Ding, Yili,Girardet, Jean-Luc,Smith, Kenneth L.,Larson, Gary,Prigaro, Brett,Wu, Jim Z.,Yao, Nanhua
, p. 26 - 38 (2008/02/07)
From random screening of our compound libraries, we identified a hit compound with an IC50 of 27 μM against hepatitis C viral NS5B RNA-dependent RNA polymerase. By using a parallel synthetic strategy, a series of its derivatives were synthesize
