877460-87-2Relevant academic research and scientific papers
Synthesis and evaluation of some novel tetrahydropyrimidine derivatives as antimicrobial and cytotoxic agents
Haiba, Mogedda E.,Fathalla, Omar A.,Zeid, Ibrahim F.,Soliman, Abdel-Mohsen M.,Abd El-Moez, Sherein I.,El-Serwy, Walaa S.
, p. 3763 - 3774 (2013)
Starting from the reaction of ethyl cyanoacetate with thiourea and the appropriate aldehydes, a series of new thiopyrimidine derivatives were prepared. Antibacterial evaluation results revealed that compounds 12b, 4c and 11b gave the highest antibacterial activity against all tested bacterial strains. Also, some of the novel compounds were evaluated as cytotoxic agents against liver cancer (HEPG2) cell line. It was noticed that some of the derivatives induced significant growth inhibition with IC50 values (ranged from 6.35 to 9.38 μg/mL) in comparison to 5-Fluorouracil after treatment (IC50: 5 μg/mL).
Parallel synthesis of 5-cyano-6-aryl-2-thiouracil derivatives as inhibitors for hepatitis C viral NS5B RNA-dependent RNA polymerase
Ding, Yili,Girardet, Jean-Luc,Smith, Kenneth L.,Larson, Gary,Prigaro, Brett,Wu, Jim Z.,Yao, Nanhua
, p. 26 - 38 (2008/02/07)
From random screening of our compound libraries, we identified a hit compound with an IC50 of 27 μM against hepatitis C viral NS5B RNA-dependent RNA polymerase. By using a parallel synthetic strategy, a series of its derivatives were synthesize
