877461-89-7Relevant academic research and scientific papers
A ring-closing yne-carbonyl metathesis of ynamides
Kurtz, Kimberly C. M.,Hsung, Richard P.,Zhang, Yanshi
, p. 231 - 234 (2007/10/03)
An acid-catalyzed ring-closing ynamide-carbonyl metathesis is described here. This hetero RCM methodology is applicable to the construction of carbocycles as well as heterocycles such as chromenes, quinolizidines, indolizidines, and pyrrolizidines.
Copper(II)-catalyzed amidations of alkynyl bromides as a general synthesis of ynamides and Z-enamides. An intramolecular amidation for the synthesis of macrocydic ynamides
Zhang, Xuejun,Zhang, Yanshi,Huang, Jian,Hsung, Richard P.,Kurtz, Kimberly C. M.,Oppenheimer, Jossian,Petersen, Matthew E.,Sagamanova, Irina K.,Shen, Lichun,Tracey, Michael R.
, p. 4170 - 4177 (2007/10/03)
A general and efficient method for the coupling of a wide range of amides with alkynyl bromides is described here. This novel amidation reaction involves a catalytic protocol using copper(II) sulfate-pentahydrate and 1,10-phenanthroline to direct the sp-C-N bond formation, leading to a structurally diverse array of ynamides including macrocyclic ynamides via an intramolecular amidation. Given the surging interest in ynamide chemistry, this atom economical synthesis of ynamides should invoke further attention from the synthetic organic community.
