Cas 877467-20-4,8-Azabicyclo[3.2.1]octane-2-carboxylic acid, 8-[(2E)-4-fluoro-2-butenyl]-3-(4-methylphenyl)-, methyl ester, (1R,2S,3S,5S)-

877467-20-4

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Basic information

Product Name: 8-Azabicyclo[3.2.1]octane-2-carboxylic acid, 8-[(2E)-4-fluoro-2-butenyl]-3-(4-methylphenyl)-, methyl ester, (1R,2S,3S,5S)-
Synonyms:
CAS NO:877467-20-4
Molecular Formula: C20H26FNO2
Molecular Weight: 331.43
EINECS: N/A
Product Categories: N/A

Chemical Properties

Melting Point: N/A
Boiling Point: N/A
Flash Point: N/A
Appearance: N/A
Density: N/A
Refractive Index: N/A
Storage Temp.: N/A
Solubility: N/A
CAS DataBase Reference: 8-Azabicyclo[3.2.1]octane-2-carboxylic acid, 8-[(2E)-4-fluoro-2-butenyl]-3-(4-methylphenyl)-, methyl ester, (1R,2S,3S,5S)-(CAS DataBase Reference)
NIST Chemistry Reference: 8-Azabicyclo[3.2.1]octane-2-carboxylic acid, 8-[(2E)-4-fluoro-2-butenyl]-3-(4-methylphenyl)-, methyl ester, (1R,2S,3S,5S)-(877467-20-4)
EPA Substance Registry System: 8-Azabicyclo[3.2.1]octane-2-carboxylic acid, 8-[(2E)-4-fluoro-2-butenyl]-3-(4-methylphenyl)-, methyl ester, (1R,2S,3S,5S)-(877467-20-4)

Safety Data

Hazard Codes: N/A
Statements: N/A
Safety Statements: N/A
WGK Germany:
RTECS:
HazardClass: N/A
PackingGroup: N/A
Hazardous Substances Data: 877467-20-4(Hazardous Substances Data)

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Check Digit Verification of cas no

The CAS Registry Mumber 877467-20-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,7,7,4,6 and 7 respectively; the second part has 2 digits, 2 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 877467-20:
(8*8)+(7*7)+(6*7)+(5*4)+(4*6)+(3*7)+(2*2)+(1*0)=224
224 % 10 = 4
So 877467-20-4 is a valid CAS Registry Number.

877467-20-4Upstream product

877467-20-4Downstream Products

877467-21-5 8-((E)-4-fluoro-but-2-enyl)-3β-p-tolyl-8-aza-bicyclo[3.2.1]octane-2β-carboxylic acid

877467-20-4Relevant academic research and scientific papers

One-step radiosynthesis of [18F]LBT-999: A selective radioligand for the visualization of the dopamine transporter with PET

Dolle, Frederic,Helfenbein, Julie,Hinnen, Francoise,Mavel, Sylvie,Mincheva, Zoia,Saba, Wadad,Schoellhorn-Peyronneau, Marie-Anne,Valette, Heric,Garreau, Lucette,Chalon, Sylvie,Halldin, Christer,Madelmont, Jean-Claude,Deloye, Jean-Bernard,Bottlaender, Michel,Le Gailliard, Joel,Guilloteau, Denis,Emond, Patrick

, p. 716 - 723 (2007)

LBT-999 (8-((E)-4-fluoro-but-2-enyl)-3-beta-p-tolyl-8-aza-bicyclo[3.2.1] octane-2-beta-carboxylicacid methyl ester) is a recently developed cocaine derivative belonging to a new generation of highly selective dopamine transporter (DAT) ligands (KD/s

Synthesis, fluorine-18 radiolabeling, and biological evaluation of N -((E)-4-fluorobut-2-en-1-yl)-2β-carbomethoxy-3β-(4?-halophenyl) nortropanes: Candidate radioligands for in vivo imaging of the brain dopamine transporter with positron emission tomograph

Stehouwer, Jeffrey S.,Daniel, Lauryn M.,Chen, Ping,Voll, Ronald J.,Williams, Larry,Plott, Susan J.,Votaw, John R.,Owens, Michael J.,Howell, Leonard,Goodman, Mark M.

experimental part, p. 5549 - 5557 (2010/11/17)

The N-(E)-fluorobutenyl-3β-(para-halo-phenyl)nortropanes 9?12 were synthesized as ligands of the dopamine transporter (DAT) for use as 18F-labeled positron emission tomography (PET) imaging agents. In vitro competition binding assays demonstrat

Synthesis and monoamine uptake inhibition of conformationally constrained 2β-carbomethoxy-3β-phenyl tropanes

Riss, Patrick Johannes,Hummerich, Rene,Schloss, Patrick

experimental part, p. 2688 - 2698 (2009/09/07)

A series of 2β-carbomethoxy-3β-phenyl tropanes with conformationally constrained nitrogen substituents were synthesized as potential selective dopamine transporter ligands. These novel compounds were examined for their monoamine uptake inhibition potency at the human dopamine transporter (hDAT), the human serotonin transporter (hSERT) and the human noradrenalin transporter (hNET), stably expressed in human embryonic kidney cells (HEK). A SAR-study was conducted to determine the contribution of extended, 4-fluorinated, conformationally constrained C4 chains at the tropane nitrogen to human monoamine transporter affinity and selectivity. The Royal Society of Chemistry 2009.

Synthesis, radiosynthesis and in vivo preliminary evaluation of [ 11C]LBT-999, a selective radioligand for the visualisation of the dopamine transporter with PET

Dolle, Frederic,Emond, Patrick,Mavel, Sylvie,Demphel, Stephane,Hinnen, Francoise,Mincheva, Zoia,Saba, Wadad,Valette, Heric,Chalon, Sylvie,Halldin, Christer,Helfenbein, Julie,Legaillard, Joel,Madelmont, Jean-Claude,Deloye, Jean-Bernard,Bottlaender, Michel,Guilloteau, Denis

, p. 1115 - 1125 (2007/10/03)

LBT-999 (8-((E)-4-fluoro-but-2-enyl)-3β-p-tolyl-8-aza-bicyclo[3.2.1] octane-2β-carboxylic acid methyl ester), a cocaine derivative belonging to a new generation of highly selective dopamine transporter (DAT) ligands, and its corresponding carboxylic acid

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