87748-00-3Relevant academic research and scientific papers
Competitive 3+2 and 2+2 cycloadditions of ester stabilized azaallyl anions to benzynes. Ring expansion of initial 3+2 products to isoquinolin-3-ones
Hussain, Helmi,Kianmehr, Ebrahim,Durst, Tony
, p. 2245 - 2248 (2007/10/03)
Reaction of the azaallyllithiums derived from imines of α-amino esters with benzynes results in the formation of 1,3-dihydroisoindoles and 4-hydroxyisoquinolines via 3+2 and 2+2 cycloadditions, respectively. The initially formed 1-carboethoxy-1,3-dihydroisoindoles rearrange under basic reaction conditions to form 3-(2H)-isoquinolinones.
HYDROGENATION OF 3(2H)-ISOQUINOLINONES AND THE STEREOCHEMISTRY OF THE PRODUCTS
Toth, Gabor,Hazai, Laszlo,Deak, Gyula,Duddeck, Helmut,Kuehne, Harald,Hricovini, Milos
, p. 6861 - 6870 (2007/10/02)
A new route of preparing 1,4-dihydro-3(2H)-isoquinolinones and 5,6,7,8-tetrahydroisoquinolinones was developed by the hydrogenation of 3(2H)-isoquinolinones.The 1,4-dihydro compounds 1-8 were also prepared by synthesis, when the cis-trans ratio significan
DIELS-ALDER REACTION OF 3(2H)-ISOQUINOLINONES, III. SYNTHESIS OF ADDUCTS WITH MALEIC ACID DERIVATIVES
Hazai, L.,Schnitta, A.,Deak, Gy.,Toth, G.,Szoelloesy, A.
, p. 99 - 116 (2007/10/02)
By reacting 3(2H)-isoquinolinones, prepared earlier by us, with N-phenylmaleimide, maleic anhydride and N-carbamoylmaleimide dienophiles, a number of Diels-Alder adducts were synthesized containing various substituents, such as alkyl, aralkyl, alkoxy, aryl and hetaryl groups.Adduct formations with isoquinolinones having an additional fused benzene ring were also examined.In some cases, when the starting 3(2H)-isoquinolinone could not be isolated as a pure compound, identification was achieved by means of the adduct obtained in the Diels-Alder reaction.
