87750-66-1

Upstream product

• 1660-94-2 Tetraethyl methylenediphosphonate 
• 529-20-4 2-methylphenyl aldehyde 
• 95-46-5 2-methylphenyl bromide 
• 682-30-4 Diethyl vinylphosphonate 
• 146064-45-1 diethyl (α-thiocyanatomethyl)phosphonate 

Downstream Products

• 149365-32-2 [(E)-2-(2-Bromomethyl-phenyl)-vinyl]-phosphonic acid diethyl ester 
• 149365-38-8 (E)-<2-<2-<(2-amino-1,6-dihydro-6-oxo-9H-purin-9-yl)methyl>phenyl>ethenyl>phosphonic acid 

Relevant academic research and scientific papers

Synthesis of diethyl 2-(aryl)vinylphosphonates by the Heck reaction catalysed by well-defined palladium complexes

Pd-catalysed procedures for the direct Heck arylation of diethyl vinylphosphonate with various aryl or heteroaryl halides toward the synthesis of diethyl 2-(aryl)vinylphosphonates are reported. Several homogeneous catalytic systems (i.e. Herrmann palladacycle, Nolan (NHC)-palladium catalyst, Pd(OAc)2/PPh3) were used and compared within the study. High conversions and selectivities were achieved under optimised conditions (2 mol% [Pd], NMP, K2CO3, 140 °C) whatever the homogeneous catalyst used.

Reaction of diethyl thiocyanatomethylphosphonate with aldehydes as a route to diethyl Z-1-alkenylphosphonates

Diastereoselective synthesis of diethyl Z-1-alkenylphosphonates from easily available diethyl thiocyanatomethylphosphonate and aromatic aldehydes has been developed. Olefination of the aldehydes occurs under mild conditions and affords the title compounds with moderate yields. A plausible mechanism of the above-mentioned reaction is also discussed.

A novel stereoselective synthesis of (E)-2-arylvinylphosphonates in InCl3-NaBH4-MeCN system

Hydroindation of arylalkynylphosphonates gives a intermediate which can be hydrolyzed to (E)-2-arylvinylphosphonates in InCl3-NaBH 4-MeCN system, the stereoselectivity and yield are rather high, but under the same conditions 2-alkylalkynylphosphonates do not react very well.

Regio- and stereoselective synthesis of 2-amino-1-hydroxy-2-aryl ethylphosphonic esters

A highly regio- and diastereoselective synthesis of 2-amino-1-hydroxy-2-aryl ethylphosphonic esters was achieved by opening trans 1,2-epoxy-2-aryl ethylphosphonic esters with 28% NH(3(aq.)) in methanol. (C) 2000 Published by Elsevier Science Ltd.

9-purinyl phosphonic acid derivitives for treating gout

This invention relates to novel purine nucleoside phosphorylase inhibitors, to the methods and intermediates for their preparation and to their use as immunosuppressants, antilymphoma, antileukemic, antiviral and antiprotozoal agents.