87752-49-6Relevant academic research and scientific papers
The Reaction of α-Substituted Ketones with N-Alkylhydroxylamines
Saeki, Seitaro,Honda, Haruyoshi,Hamana, Masamoto
, p. 1474 - 1481 (2007/10/02)
N-Methyl and N-benzylhydroxylamine reacted smoothly with ethyl acetoacetate to afford pyrroline compounds 1 and 2, respectively.On the other hand, the reaction of N-cyclohexylhydroxylamine gave the nitrone compound 3.Other active methylene compounds, i.e. diethyl acetonedicarboxylate, benzoylacetone and nitroacetone, reacted with methylhydroxylamine to give the N-methylpyrrole 6, the nitrone 7 and the isoxazoline 8, respectively. Keywords---cyclization; N-alkylhydroxylamine; active methylene compounds; nitrone; isoxazoline; pyrrole; pyrroline
