87759-75-9Relevant academic research and scientific papers
ENZYMATIC IN VITRO REDUCTION OF KETONES. PART 11. THE UNEXPECTED STERIC COURSE OF THE HLAD CATALYZED REDUCTION OF 3-CYANOCYCLOHEXANONE.
Willaert, Jan J.,Lemiere, Guy L.,Dommisse, Roger A.,Lepoivre, Joseph A.,Alderweireldt, Frank C.
, p. 139 - 150 (2007/10/02)
3-Cyanocyclohexanone is a suitable substrate for preparative HLAD reduction, delivering enantiomerically pure (1S,3S)-trans and (1R,3S)-cis alcohols.Details are given on the kinetics of the reduction and the absolute configuration of the products.In contr
Use of Shift Reagent with MTPA Derivatives in 19F NMR Spectroscopy IV - Determination of Enantiomeric Composition for a Variety of Secondary Cycloalkanols. A Survey
Merckx, E. M.,Lepoivre, J. A.,Lemiere, G. L.,Alderweireldt, F. C.
, p. 380 - 387 (2007/10/02)
Chiral secondary cycloalkanols (monpocyclic alcohols) are derivatized to the corresponding (R)-α-methoxy-α-trifluoromethyl-α-phenylacetic acid esters and analysed by 19F NMR in the presence of tris(6,6,7,7,8,8,8-heptafluoro-2,2-dimethyl-3,5-octanedionato)europium(III) .Using this method the enantiomeric composition can be measured for severak cyclopentanols, cyclohexanols and cycloheptanols, with a variety of substitution patterns.It is shown that a mixture of four stereoisomeric cycloalkanols, such as cis and trans disubstituted alcohols, can be analysed simultaneously.
