877636-42-5Relevant articles and documents
SMALL MOLECULE ANTAGONISTS OF THE APELIN RECEPTOR FOR THE TREATMENT OF DISEASE
-
, (2014/02/15)
The present disclosure relates to compounds and methods for treating a disease mediated by apelin.
877636-42-5
Post Buying Request-
-
Basic information
- Product Name: 5-[(4-Nitrobenzoyl)oxy]-2-[(2-pyrimidinylthio)methyl]-4H-pyran-4-one
- Synonyms: 5-[(4-Nitrobenzoyl)oxy]-2-[(2-pyrimidinylthio)methyl]-4H-pyran-4-one;ML221
- CAS NO:877636-42-5
- Molecular Formula: C17H11N3O6S
- Molecular Weight: 385.35074
- EINECS: N/A
- Product Categories: API
- Mol File: 877636-42-5.mol
- Article Data: 2
-
Chemical Properties
- Melting Point: N/A
- Boiling Point: 624.1±55.0 °C(Predicted)
- Flash Point: N/A
- Appearance: white to beige/
- Density: 1.54±0.1 g/cm3(Predicted)
- Refractive Index: N/A
- Storage Temp.: 2-8°C
- Solubility: DMSO: soluble5mg/mL, clear (warmed)
- PKA: 0.30±0.33(Predicted)
- CAS DataBase Reference: 5-[(4-Nitrobenzoyl)oxy]-2-[(2-pyrimidinylthio)methyl]-4H-pyran-4-one(CAS DataBase Reference)
- NIST Chemistry Reference: 5-[(4-Nitrobenzoyl)oxy]-2-[(2-pyrimidinylthio)methyl]-4H-pyran-4-one(877636-42-5)
- EPA Substance Registry System: 5-[(4-Nitrobenzoyl)oxy]-2-[(2-pyrimidinylthio)methyl]-4H-pyran-4-one(877636-42-5)
-
Safety Data
- Hazard Codes: N/A
- Statements: N/A
- Safety Statements: N/A
- WGK Germany: 3
- RTECS:
- HazardClass: N/A
- PackingGroup: N/A
- Hazardous Substances Data: 877636-42-5(Hazardous Substances Data)
877636-42-5 Suppliers
Recommended suppliersmore
877636-42-5 Usage
Description
ML-221 is an antagonist of the G protein-coupled receptor (GPCR) APJ (IC50 = 4.8 μM). It is selective for APJ over the angiotensin II type 1 (AT1) receptor (IC50 = >78 μM). ML-221 antagonizes apelin 13-induced activation of APJ in cAMP and β-arrestin recruitment assays (IC50s = 0.7 and 1.75 μM, respectively). It inhibits proliferation and angiogenesis in Mz-ChA-1 cholangiocarcinoma cells when used at concentrations ranging from 5 to 15 μM. In vivo, ML-221 (150 μg/kg) reduces tumor growth in a Mz-ChA-1 mouse xenograft model. Intrathecal injection of ML-221 (10 μg per animal) reduces mechanical allodynia and heat hyperalgesia induced by chronic constriction injury (CCI) of the sciatic nerve in rats. ML-221 also inhibits pathological angiogenesis and enhances normal vessel recovery in retinal ischemic regions in a mouse model of oxygen-induced retinopathy.Uses
ML 221 is a functional antagonist of the apelin (APJ) receptor which is shown to treat or mediate the homeostasis of the cardiovascular system.Check Digit Verification of cas no
The CAS Registry Mumber 877636-42-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,7,7,6,3 and 6 respectively; the second part has 2 digits, 4 and 2 respectively.Calculate Digit Verification of CAS Registry Number 877636-42:
(8*8)+(7*7)+(6*7)+(5*6)+(4*3)+(3*6)+(2*4)+(1*2)=225
225 % 10 = 5
So 877636-42-5 is a valid CAS Registry Number.
877636-42-5 Well-known Company Product Price
877636-42-5Upstream product
877636-42-5Downstream Products
Post a RFQ
1
What can I do for you?
Get Best Price
Get Best Price for 877636-42-5
5-[(4-Nitrobenzoyl)oxy]-2-[(2-pyrimidinylthio)methyl]-4H-pyran-4-one
