877772-09-3

Upstream product

• 1443666-05-4 methyl 2-(2-chloro-4-(trifluoromethyl)phenyl)-2-oxoacetate 
• 1443666-03-2 C₉H₅ClF₃NO₂ 
• 1443666-06-5 methyl 2-(2-chloro-4-(trifluoromethyl)phenyl)-2-(2-(2,4-dichlorobenzyl)hydrazono)acetate 
• 1443666-02-1 C₉H₃ClF₃NO 
• 877773-17-6 6-Trifluoromethyl-1H-indazole-3-carboxylic acid methyl ester 
• 13544-07-5 methyl 2-(2-nitro-4-(trifluoromethyl)phenyl)acetate 
• 290825-52-4 dimethyl 2-(2-nitro-4-trifluoromethylphenyl)malonate 
• 121-17-5 2-chloro-3-nitro-5-trifluoromethylbenzene 
• 877766-37-5 methyl 1-(2,4-dichlorobenzyl)-6-(trifluoromethyl)-1H-indazole-3-carboxylate 

Downstream Products

• 877766-69-3 3-[1-(2,4-dichlorobenzyl)-6-trifluoromethyl-1H-indazol-3-yl]-propionic acid ethyl ester 
• 877768-45-1 trans-2-[1-(2,4-dichloro-benzyl)-6-trifluoromethyl-1H-indazol-3-yl]-cyclopropanecarboxylic acid 
• 877768-41-7 3-[1-(2,4-dichlorobenzyl)-6-trifluoromethyl-1H-indazol-3-yl]-oxirane-2-carboxylic acid 
• 877768-84-8 H₂-gamendazole 
• 877766-73-9 3-[1-(2,4-dichlorobenzyl)-6-trifluoromethyl-1H-indazol-3-yl]-acrylic acid ethyl ester 
• 877768-95-1 3-[1-(2,4-dichlorobenzyl)-5-trifluoromethyl-1H-indazol-3-yl]-propionic acid 
• 877773-21-2 1-(2,4-dichlorobenzyl)-6-(trifluoromethyl)-1H-indazole-3-carbaldehyde 

Relevant academic research and scientific papers

Total syntheses of AF-2785 and gamendazole-experimental male oral contraceptives

Both AF-2785 and gamendazole are experimental male oral contraceptives. The total syntheses of these two compounds are achieved in good yields. Copyright

LONIDAMINE ANALOGUES FOR FERTILITY MANAGEMENT

Fertility management can include: administering to the subject one or more doses of a compound according to Formula I so as to reduce fertility in the subject. Fertility management can also include administering an effective amount of the compound to: impair Sertoli cell function in a male subject; inhibit spermatogenesis in the subject; reduce testis weight in the subject; reduce ovary weight in a female subject; reduce serum progesterone in the female subject; impair ovarian follicle function in the female subject; causing reversible fertility in the subject. In order to return fertility, the method can include ceasing administration of the compound to the subject so as to return fertility in the subject. The compound can be administered for irreversibly sterilizing the subject.

Lonidamine analogues and their use in male contraception and cancer treatment

Novel compounds useful for inhibiting spermatogenesis and cancer treatment, and in particular as inhibitors of heat shock proteins and/or elongation factor 1 alpha.