877806-38-7

Basic information

• Product Name: C₁₇H₁₇N₃O₃S
• CAS NO: 877806-38-7
• Molecular Weight: 343.406
• Mol File: 877806-38-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₁₇H₁₇N₃O₃S(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₇H₁₇N₃O₃S(877806-38-7)
• EPA Substance Registry System: C₁₇H₁₇N₃O₃S(877806-38-7)

Safety Data

• Hazardous Substances Data: 877806-38-7(Hazardous Substances Data)

Upstream product

• 3189-13-7 6-methoxylindole 
• 70555-46-3 6-methoxy-1H-indole-3-carbaldehyde 
• 1576-35-8 toluene-4-sulfonic acid hydrazide 

Downstream Products

• 1640122-70-8 N-acetyl-3-(4-methoxyphenyl)-3-methyl-6-methoxyindoline 

Relevant articles and documents

Regioselective hydroarylation reactions of C3 electrophilic N-acetylindoles activated by FeCl3: An entry to 3-(Hetero)arylindolines

A method for the direct and rare umpolung of the 3 position of indoles is reported. The activation of N-acetylindole with iron(III) chloride allows the C-H addition of aromatic and heteroaromatic substrates to the C2-C3 double bond of the indole nucleus to generate a quaternary center at C3 and leads regioselectively to 3-arylindolines. Optimization, scope (50 examples), practicability (gram scale, air atmosphere, room temperature), and mechanistic insights of this process are presented. Synthetic transformations of the indoline products into drug-like compounds are also described.