877874-61-8Relevant articles and documents
COMPOUNDS USEFUL AS ANTIBIOTIC TOLERANCE INHIBITORS
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Page/Page column 36, (2014/11/13)
The disclosure provides compounds and pharmaceutical compositions of the compounds useful for treating chronic and acute bacterial infections. Certain of the compounds are compounds and salts of general Formula VIII Certain compounds of this disclosure are MvfR inhibitors. MvfR inhibitors reduce the formation of antibiotic tolerant bacterial strains and are useful for treating Gram-negative bacterial infections and reducing the virulence of Pseudomonas aeruginosa. Methods of treating bacterial infections in a patient, including Pseudomonas aeruginosa infections, are also provided by the disclosure.
HETEROCYCLIC COMPOUNDS AND METHODS OF USE
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Page/Page column 84, (2010/10/20)
Heterocyclic compounds derived from benzotriazine, triazines, triazoles and oxadiazoles are disclosed. The methods of synthesis and of use of such heterocyclic compounds are also provided.