87789-42-2

Upstream product

• 1112401-07-6 C₁₀H₁₀Cl₂O₃ 
• 383898-16-6 (-)-ethyl 2-(2,6-dichlorophenoxy)propionate 

Downstream Products

• 81447-78-1 (-)-Lofexidine 
• 101934-14-9 1,3-Dichloro-2-((R)-2,2,2-triethoxy-1-methyl-ethoxy)-benzene 
• 101934-13-8 (R)-2-(2,6-Dichloro-phenoxy)-propionimidic acid ethyl ester; hydrochloride 
• 1112401-11-2 C₁₀H₁₁Cl₂NO₂ 
• 86981-81-9 (-)-2-(2,6-dichlorophenoxy)propionitrile 

Relevant academic research and scientific papers

ENANTIOSELECTIVE SYNTHESIS OF (+) AND (-)-2-[1-(2,6-DICHLOROPHENOXY)-ETHYL]-1,3-DIAZACYCLOPENT-2-3ENE

This application provides a method for the enantioselective synthesis of (+) and (?) lofexidine or 2-[1-(2,6)-dichlorophenoxy)-ethyl]-1,3-diazacyclopent-2-ene.

A scalable, enantioselective synthesis of the r2-adrenergic agonist, lofexidine

A scalable and high-yielding synthetic route toward pure enantiomers of the α2-adrenergic agonist, lofexidine hydrochloride, is presented. Salient features include a rapid one-pot amide alkylation-imidazoline formation sequence on the carboxami