877994-06-4

Usage

Uses

Used in Pharmaceutical Industry:
5-Methoxypyrazolo[1,5-a]pyridine is used as a key intermediate in the synthesis of various drugs and bioactive compounds due to its unique structure and pharmacological properties. Its anti-inflammatory, analgesic, and antioxidant properties contribute to the development of new pharmaceuticals that can address a range of health conditions.
Used in Organic Chemistry:
In the field of organic chemistry, 5-Methoxypyrazolo[1,5-a]pyridine serves as a reagent for the synthesis of other heterocyclic compounds. Its presence in various chemical reactions allows for the creation of complex molecules with potential applications in different industries, including pharmaceuticals, agrochemicals, and materials science.

Upstream product

• 156969-42-5 pyrazolo<1,5-a>pyridin-5-ol 
• 74-88-4 methyl iodide 
• 99446-53-4 ethyl 5-methoxypyrazolo[1,5-a]pyridine-3-carboxylate 
• 620-08-6 4-methoxypyridine 
• 99446-31-8 5-methoxy-pyrazolo[1,5-a]pyridine-3-carboxylic acid methyl ester 

Downstream Products

• 1101118-13-1 N'-((5-methoxypyrazolo[1,5-a]pyridin-3-yl)methylene)-N,2-dimethyl-5-nitrobenzenesulfonohydrazide 

Relevant academic research and scientific papers

Discovery of pyrazolo[1,5-a]pyridines as p110α-selective PI3 kinase inhibitors

We have made a novel series of pyrazolo[1,5-a]pyridines as PI3 kinase inhibitors, and demonstrated their selectivity for the p110α isoform over the other Class Ia PI3 kinases. We investigated the SAR around the pyrazolo[1,5-a]pyridine ring system, and found compound 5x to be a particularly potent example (p110α IC50 0.9 nM). This compound inhibits cell proliferation and phosphorylation of Akt/PKB, a downstream marker of PI3 kinase activity, and showed in vivo activity in an HCT-116 human xenograft model.

PYRAZOLO[1,5-A]PYRIDINES AND THEIR USE IN CANCER THERAPY

Pyrazolo[1,5-a]pyridines are described, including methods for their preparation, and their use as agents or drugs for cancer therapy, both alone or in combination with radiation and/or other anticancer drugs.

Bicyclic melatonin receptor agonists containing a ring-junction nitrogen: Synthesis, biological evaluation, and molecular modeling of the putative bioactive conformation

Employing 1,3-dipolar cycloaddition for the synthesis of the 7a-azaindole nucleus, analogues of melatonin have been synthesized and tested against human and amphibian melatonin receptors. Introducing a phenyl substituent in position 2 of the heterocyclic