877994-06-4

Basic information

• Product Name: 5-Methoxypyrazolo[1,5-a]pyridine
• Synonyms: 5-Methoxypyrazolo[1,5-a]pyridine
• CAS NO: 877994-06-4
• Molecular Formula: C8H8N2O
• Molecular Weight: 148.16192
• Mol File: 877994-06-4.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 5-Methoxypyrazolo[1,5-a]pyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Methoxypyrazolo[1,5-a]pyridine(877994-06-4)
• EPA Substance Registry System: 5-Methoxypyrazolo[1,5-a]pyridine(877994-06-4)

Safety Data

• Hazardous Substances Data: 877994-06-4(Hazardous Substances Data)

Usage

General Description

5-Methoxypyrazolo[1,5-a]pyridine is a chemical compound with the molecular formula C7H6N2O. It is a heterocyclic compound that consists of a pyrazole ring fused to a pyridine ring with a methoxy group attached to the pyrazole ring. 5-Methoxypyrazolo[1,5-a]pyridine is commonly used in the pharmaceutical industry for the synthesis of various drugs and bioactive compounds. 5-Methoxypyrazolo[1,5-a]pyridine has been found to exhibit anti-inflammatory, analgesic, and antioxidant properties, which makes it a valuable building block for the development of new pharmaceuticals. Additionally, this chemical is also utilized as a reagent in organic chemistry for the synthesis of other heterocyclic compounds. Overall, 5-Methoxypyrazolo[1,5-a]pyridine plays a crucial role in the development of new drugs and has various applications in the field of organic chemistry.

Upstream product

• 99446-53-4 ethyl 5-methoxypyrazolo[1,5-a]pyridine-3-carboxylate 
• 620-08-6 4-methoxypyridine 
• 99446-31-8 5-methoxy-pyrazolo[1,5-a]pyridine-3-carboxylic acid methyl ester 
• 156969-42-5 pyrazolo<1,5-a>pyridin-5-ol 
• 74-88-4 methyl iodide 

Downstream Products

• 1101118-13-1 N'-((5-methoxypyrazolo[1,5-a]pyridin-3-yl)methylene)-N,2-dimethyl-5-nitrobenzenesulfonohydrazide 

Relevant articles and documents

Discovery of pyrazolo[1,5-a]pyridines as p110α-selective PI3 kinase inhibitors

We have made a novel series of pyrazolo[1,5-a]pyridines as PI3 kinase inhibitors, and demonstrated their selectivity for the p110α isoform over the other Class Ia PI3 kinases. We investigated the SAR around the pyrazolo[1,5-a]pyridine ring system, and found compound 5x to be a particularly potent example (p110α IC50 0.9 nM). This compound inhibits cell proliferation and phosphorylation of Akt/PKB, a downstream marker of PI3 kinase activity, and showed in vivo activity in an HCT-116 human xenograft model.

Bicyclic melatonin receptor agonists containing a ring-junction nitrogen: Synthesis, biological evaluation, and molecular modeling of the putative bioactive conformation

Employing 1,3-dipolar cycloaddition for the synthesis of the 7a-azaindole nucleus, analogues of melatonin have been synthesized and tested against human and amphibian melatonin receptors. Introducing a phenyl substituent in position 2 of the heterocyclic