878-17-1

Basic information

• Product Name: p-Tolyl phosphorodichloridate
• Synonyms: p-Tolyl phosphorodichloridate;4-Tolyl phosphorodichloridate
• CAS NO: 878-17-1
• Molecular Formula: C₇H₇Cl₂O₂P
• Molecular Weight: 225.009
• Mol File: 878-17-1.mol
• Article Data: 10

Chemical Properties

• Boiling Point: 265.2 °C at 760 mmHg
• Flash Point: 129 °C
• Appearance: /
• Density: 1.405g/cm³
• Vapor Pressure: 0.0153mmHg at 25°C
• Refractive Index: 1.533
• CAS DataBase Reference: p-Tolyl phosphorodichloridate(CAS DataBase Reference)
• NIST Chemistry Reference: p-Tolyl phosphorodichloridate(878-17-1)
• EPA Substance Registry System: p-Tolyl phosphorodichloridate(878-17-1)

Safety Data

• Hazardous Substances Data: 878-17-1(Hazardous Substances Data)

Usage

General Description

p-Tolyl phosphorodichloridate is a chemical compound with the molecular formula C7H7Cl2O2P. It is a colorless, oily liquid that is used as a versatile intermediate in the production of various organic phosphorus compounds for applications in pharmaceuticals, agrochemicals, and other industries. It is mainly used in the synthesis of phosphonate and phosphonite derivatives, which have biological and industrial significance. p-Tolyl phosphorodichloridate is also utilized as a coupling reagent in peptide synthesis and as a precursor in the preparation of chiral phosphine ligands for catalysis. Due to its application as an intermediate in the production of several important compounds, this chemical has significant industrial importance and is widely used in various chemical processes.

InChI:InChI=1/C7H7Cl2O2P/c1-6-2-4-7(5-3-6)11-12(8,9)10/h2-5H,1H3

Upstream product

• 106-44-5 p-cresol 
• 10025-87-3 trichlorophosphate 

Downstream Products

• 84957-80-2 2-p-Tolyloxy-octahydro-benzo[1,3,2]diazaphosphole 2-oxide 
• 21283-93-2 4-MeC₆H₄OP(O)(NHBn)2 
• 283178-36-9 2,10-dichloro-6-(4'-methylphenoxy)-4,8-dinitrodibenzo[d,g][1,3,6,2]dioxathiaphosphocin-6-oxide 
• 201744-75-4 2-(p-methylphenoxy)-1,3,6,2-dioxaselenaphosphocane 2-oxide 
• 76628-07-4 C₇H₇F₂O₂P 
• 57193-37-0 diamidophosphoric acid p-tolyl ester 
• 130557-83-4 4-p-Tolyloxy-3,5-dioxa-4-phospha-cyclohepta[2,1-a;3,4-a']dinaphthalene 4-oxide 
• 125790-30-9 C₁₉H₁₅Cl₂N₂O₃P 

Relevant articles and documents

Prodrug compound and application ofprodrug compound in treatment of cancer

The present invention provides a compound indicated by a formula (I), pharmaceutically acceptable salts or esters thereof, a pharmaceutical composition of the compound, and application of the compoundand the pharmaceutical composition in the inhibition or regulation of the activity of tyrosine kinase and treating disease symptoms or symptoms including cancer mediated by tyrosine kinase.

Synthesis, characterization and thermal studies of cresol based polyphosphate esters

Polyphosphate esters were synthesized from cresol phosphorodichloridates and dihydric phenols by interfacial polycondensation using a phase transfer catalyst. The polymers were characterized by IR, 1H and 31P NMR spectroscopy and GPC. The thermal stability of the polymers was determined by thermogravimetry.

Aryl phosphoramidates of 5-phospho erythronohydroxamic acid, a new class of potent trypanocidal compounds

RNAi and enzymatic studies have shown the importance of 6-phosphogluconate dehydrogenase (6-PGDH) in Trypanosoma brucei for the parasite survival and make it an attractive drug target for the development of new treatments against human African trypanosomi