878-86-4

Basic information

• Product Name: 6-chloro-3-methyl-5-nitropyrimidine-2,4(1H,3H)-dione
• CAS NO: 878-86-4
• Molecular Formula: C₅H₄ClN₃O₄
• Molecular Weight: 205.556
• Mol File: 878-86-4.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 279.7°C at 760 mmHg
• Flash Point: 122.9°C
• Density: 1.73g/cm³
• Vapor Pressure: 0.000478mmHg at 25°C
• Refractive Index: 1.611
• CAS DataBase Reference: 6-chloro-3-methyl-5-nitropyrimidine-2,4(1H,3H)-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 6-chloro-3-methyl-5-nitropyrimidine-2,4(1H,3H)-dione(878-86-4)
• EPA Substance Registry System: 6-chloro-3-methyl-5-nitropyrimidine-2,4(1H,3H)-dione(878-86-4)

Safety Data

• Hazardous Substances Data: 878-86-4(Hazardous Substances Data)

Usage

General Description

6-chloro-3-methyl-5-nitropyrimidine-2,4(1H,3H)-dione is a chemical compound with the molecular formula C6H4ClN3O4. It is an organic compound that belongs to the class of nitropyrimidines. This chemical is a yellow to orange crystalline solid and is mainly used as an intermediate in the synthesis of various pharmaceuticals and agrochemicals. It is also known for its antimicrobial properties and can be used in the manufacturing of antibacterial agents. Additionally, it has potential application in the field of organic synthesis and medicinal chemistry due to its unique structure and properties.

Upstream product

• 2565-47-1 1-methyl-2,4,6-pyrimidinetrione 
• 4318-56-3 3-methyl-6-chlorouracil 
• 89466-43-3 6-chloro-3-methyl-2-methylthio-4(3H)-pyrimidinone 
• 6945-56-8 6-hydroxy-3-methyl-2-methylthio-4(3H)-pyrimidinone 
• 4318-56-3 6-chloro-2-hydroxy-3-methyl-4(3H)-pyrimidinone 

Downstream Products

• 63711-21-7 6-Anilino-3-methyl-5-nitrouracil 
• 1207462-43-8 C₁₈H₁₄FN₅O₅ 
• 1207462-45-0 C₁₇H₁₄FN₅O₅ 
• 1207462-46-1 C₁₉H₁₆BrN₅O₅ 
• 1207462-47-2 6-[2-(4-fluorobenzylidene)-1-(4-methoxyphenyl)hydrazinyl]-3-methyl-5-nitropyrimidine-2,4(1H,3H)-dione 
• 1207462-48-3 C₁₅H₁₇N₅O₅ 
• 1207462-49-4 C₁₄H₁₄ClN₅O₅ 
• 1207462-50-7 C₁₆H₁₉N₅O₇ 
• 1207462-51-8 6-[1-isopropyl-2-(4-methoxybenzylidene)hydrazinyl]-3-methyl-5-nitropyrimidine-2,4(1H,3H)-dione 
• 1207462-60-9 C₁₃H₁₂FN₅O₄ 
• 1207462-61-0 C₁₃H₁₂FN₅O₄ 
• 1207462-63-2 C₁₄H₁₄FN₅O₅ 
• 1207462-64-3 6-[2-(4-fluoro-3-methoxybenzylidene)-1-methylhydrazinyl]-3-methyl-5-nitropyrimidine-2,4(1H,3H)-dione 
• 1207462-44-9 C₁₉H₁₆FN₅O₅ 

Relevant articles and documents

Synthesis and quantitative structure-activity relationship (QSAR) analysis of some novel oxadiazolo[3,4-d]pyrimidine nucleosides derivatives as antiviral agents

We have synthesized a series of 4H,6H-[1,2,5]oxadiazolo[3,4-d]pyrimidine-5,7-dione 1-oxide nucleoside and their anti-vesicular stomatitis virus (VSV) activities in Wish cell were also investigated in vitro. It was found that most compounds showed obvious anti-VSV activities and compound 9 with ribofuranoside improved the anti-VSV activity by approximately 10 times and 18 times compared to didanosine (DDI) and acyclovir, respectively. A quantitative structure-activity relationship (QSAR) study of these compounds as well as previous reported oxadiazolo[3,4-d]pyrimidine nucleoside derivatives indicated that compounds with high activity should have small values of log P(o/w), vsurf-G and a large log S value. These findings and results provide a base for further investigations.

PURINES AND PYRIMIDINES AND CONDENSED SYSTEMS BASED ON THEM. 2. SYNTHESIS OF 1-METHYL-9-AMINOXANTHINE AND 9-AMINOTHEOPHYLLINE

The previously unknown 9-aminotheophylline and 1-methyl-9-aminoxanthine were synthesized from 3-methyl-5-amino-6-hydrazinouracil.In the case of 1-methyl-9-aminoxanthine an x-ray diffraction study of an N-amino derivative of an NH heterocycle was made for the first time.