87810-56-8 Usage
Uses
Fostriecin is the most fully characterised member of a family of phosphate esters of a triene antibiotic. The antitumour potential of fostriecin has attracted considerable interest, focused on its mode of action as a topoisomerase II inhibitor. Subsequent research has focused on this metabolite's selective inhibition of protein phosphatase PP2A.
Check Digit Verification of cas no
The CAS Registry Mumber 87810-56-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,7,8,1 and 0 respectively; the second part has 2 digits, 5 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 87810-56:
(7*8)+(6*7)+(5*8)+(4*1)+(3*0)+(2*5)+(1*6)=158
158 % 10 = 8
So 87810-56-8 is a valid CAS Registry Number.
InChI:InChI=1/C19H27O9P/c1-19(23,12-11-16-9-7-10-18(22)27-16)17(28-29(24,25)26)14-15(21)8-5-3-2-4-6-13-20/h2-8,10-12,15-17,20-21,23H,9,13-14H2,1H3,(H2,24,25,26)/b3-2-,6-4+,8-5-,12-11+/t15-,16-,17+,19+/m0/s1
87810-56-8Relevant articles and documents
Total synthesis of (+)-fostriecin and (+)-phoslactomycin B
Shibahara, Setsuya,Fujino, Masataka,Tashiro, Yasumasa,Okamoto, Nanako,Esumi, Tomoyuki,Takahashi, Keisuske,Ishihara, Jun,Hatakeyama, Susumi
experimental part, p. 2935 - 2953 (2010/03/03)
(+)-Fostriecin and (+)-phoslactomycin B, which are potent and selective inhibitors of protein phosphatase, were synthesized by a highly enantio-and stereoselective approach that enabled us to prepare all possible isomers at both the C11 secondary alcohol position and the δ12-double bond. Georg Thieme Verlag Stuttgart.
Total synthesis of fostriecin (CI-920) via a convergent route
Miyashita, Kazuyuki,Ikejiri, Masahiro,Kawasaki, Hitomi,Maemura, Satoko,Imanishi, Takeshi
, p. 742 - 743 (2007/10/03)
Fostriecin, a potent and promising antitumor antibiotic, was stereoselectively synthesized via a convergent route involving a three-segement coupling procedure.
