878155-22-7

Basic information

• Product Name: 8-amino-2-methyl-3,4-dihydroisoquinolin-1(2H)-one
• Synonyms: 8-amino-2-methyl-3,4-dihydroisoquinolin-1(2H)-one
• CAS NO: 878155-22-7
• Molecular Formula: C10H12N2O
• Molecular Weight: 176.21508
• Mol File: 878155-22-7.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 8-amino-2-methyl-3,4-dihydroisoquinolin-1(2H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 8-amino-2-methyl-3,4-dihydroisoquinolin-1(2H)-one(878155-22-7)
• EPA Substance Registry System: 8-amino-2-methyl-3,4-dihydroisoquinolin-1(2H)-one(878155-22-7)

Safety Data

• Hazardous Substances Data: 878155-22-7(Hazardous Substances Data)

Usage

Uses

An alternative microwave-assisted synthesis of 8-Amino-3,4-dihydro-2-methyl-1(2H)-isoquinolinone has been examined. The synthesis includes two one-?pot procedures in which the key process involves the microwave-?assisted hydrolysis of a nitrile group followed by lactamization under elevated temps.

Upstream product

• 878160-03-3 8-nitro-2-methyl-3,4-dihydroisoquinoline-1(2H)-one 
• 1885-76-3 2-cyano-3-nitrotoluene 
• 1201935-34-3 2-methyl-8-nitro-3,4-dihydroisoquinolin-1(2H)-imine 
• 1201935-33-2 (E)-2-(2-(methylamino)vinyl)-6-nitrobenzonitrile 
• 61940-21-4 methyl 2-(bromomethyl)-6-nitrobenzoate 
• 135484-76-3 Methyl 2-Bromo-6-nitrobenzoate 
• 38876-67-4 2-bromo-6-nitrobenzoic acid 
• 61940-22-5 methyl 2-methyl-6-nitrobenzoate 
• 55289-35-5 2-bromo-6-nitrotoluene 
• 13506-76-8 2-methyl-6-nitrobenzoic acid 
• 878160-02-2 2-(2-methoxycarbonylamino-ethyl)-6-nitro-benzoic acid methylester 
• 878160-01-1 2-(2-carboxy-ethyl)-6-nitro-benzoic acid methyl ester 
• 878160-00-0 2-(3-hydroxy-propyl)-6-nitro-benzoic acid methyl ester 
• 878159-99-0 methyl 2-allyl-6-nitrobenzoate 

Relevant articles and documents

CXCR7 RECEPTOR MODULATORS

The present invention relates to derivatives of formula (I) Formula (I) wherein (R1)n, R 2a, R 2b, R 3a, R 3b, R 4, L1, L2, X, Y and Ar1 are as described in the description, to their preparation, to pharmaceutically acceptable salts thereof, and to their use as pharmaceuticals, to pharmaceutical compositions containing one or more compounds of formula (I), and especially to their use as CXCR7 receptor modulators.

A microwave-assisted alternative synthesis of 8-amino-2-methyl-3,4- dihydroisoquinolin-1-one

A shorter, alternative synthesis of 8-amino-2-methyl-3,4- dihydroisoquinolin-1-one is described in 32% overall yield, over three steps starting from commercially available 2-methyl-6-nitrobenzonitrile. The synthesis includes two 'one-pot' procedures in wh